Inhalation developmental toxicology studies: Acetonitrile in rats. Final report

Technical Report · Tue Feb 01 04:00:00 EST 1994

DOI:https://doi.org/10.2172/10133391· OSTI ID:10133391

Mast, T J; Weigel, R J; Westerberg, R B; Boyd, P J; Hayden, B K; Evanoff, J J; Rommereim, R L

The potential for acetonitrile to cause developmental toxicity was assessed in Sprague-Dawley rats exposed to 0, 100, 400, or 1200 ppM acetonitrile, 6 hours/day, 7 days/week. Exposure of rats to these concentrations of acetonitrile resulted in mortality in the 1200 ppM group (2/33 pregnant females; 1/10 non-pregnant females). However, there were no treatment-related effects upon body weights or reproduction indices at any exposure level, nor was there a significant increase in the incidence of fetal malformations or variations. The only effect observed in the fetuses was a slight, but not statiscally significant, exposure-correlated increase in the incidence of supernumerary ribs. Determination of acetonitrile and cyanide concentrations in maternal rat blood showed that acetonitrile concentration in the blood increased with exposure concentration for all exposed maternal rats. Detectable amounts of cyanide in the blood were found only in the rats exposed to 1200 ppM acetonitrile ({approximately}2 {mu}g cyanide/g of blood).

• Research Organization: Pacific Northwest Lab., Richland, WA (United States)
• Sponsoring Organization: Department of Health and Human Services, Washington, DC (United States)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 10133391
• Report Number(s): PNL--9401; ON: DE94008272
• Country of Publication: United States
• Language: English

Related Subjects

560300
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETONITRILE
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
CHEMICALS METABOLISM AND TOXICOLOGY
EXPERIMENTAL DATA
FEMALES
FETUSES
INHALATION
MORTALITY
PREGNANCY
PRENATAL EXPOSURE
PROGRESS REPORT
RATS
WEIGHT