The effect of isotope on the dosimetry of inhaled plutonium oxide

Conference · Tue Dec 31 04:00:00 EST 1991

OSTI ID:10108381

Hickman, A W ^[1]

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1. Florida Univ., Gainesville, FL (United States)

Results of experimental studies in which animals inhaled {sup 238}PuO{sub 2} or {sup 239}PuO{sub 2} aerosols have shown that the biokinetics and associated radiation dose patterns for these two isotopes differ significantly due to differences in in-vivo solubility caused by the 260-fold difference in specific activity between {sup 238}PuO{sub 2} and {sup 239}PuO{sub 2}. We have adapted a biokinetics and dosimetry model derived from results of the ITRI dog studies to humans and have calculated dose commitments and annual limits on intake (ALI) for both Pu isotopes. Our results show that the ALI calculated in this study is one-third that for class Y {sup 238}Pu from ICRP 30, and one-half or equal to that for class Y {sup 239}Pu, depending on how activity in the thoracic lymph nodes is treated dosimetrically.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 10108381
• Report Number(s): CONF-920501--9; ON: DE92004257
• Country of Publication: United States
• Language: English

Related Subjects

560161
560162
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS, PLANTS, MICROORGANISMS, AND CELLS
ANNUAL LIMIT OF INTAKE
DOGS
DOSE COMMITMENTS
DOSIMETRY
INHALATION
LIVER
LUNGS
MAN
PLUTONIUM OXIDES
RADIOCHEMICAL ANALYSIS
RADIONUCLIDE KINETICS
SKELETON