Dosimetry of /sup 239/Pu in dogs that inhaled monodisperse aerosols of /sup 239/PuO2

Journal Article · Fri May 01 00:00:00 EDT 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576899· OSTI ID:6497201

Guilmette, R A; Muggenburg, B A; Hahn, F F; Mewhinney, J A; Seiler, F A; Boecker, B B; McClellan, R O

Existing data from human exposure cases and experimental animal studies on the fate and dosimetry of inhaled insoluble Pu particles are inadequate to provide a comprehensive description and evaluation of the tissues at risk from the alpha radiations of Pu. To improve our knowledge of the dosimetry of inhaled insoluble /sup 239/PuO/sub 2/, this paper describes the uptake and retention of /sup 239/Pu in the tissues of dogs that received single inhalation exposures to monodisperse aerosols of /sup 239/PuO/sub 2/. These data include times through 3 years after exposure. Using analytical functions fitted to each tissue data set, 1100-day radiation doses were calculated for lung, liver, skeleton, kidney, spleen, and tracheobronchial, mediastinal, sternal, hepatic, mandibular, and retropharyngeal lymph nodes. The dosimetry results suggest that the lung and lymph nodes associated with lymphatic drainage of the respiratory tract are the principal sites of alpha irradiation. However, the doses for the different respiratory tract lymph nodes vary by a factor of 2000, suggesting that assuming equivalent doses to respiratory tract lymph nodes is not appropriate. Other tissues receive radiation doses also but at levels one to three orders of magnitude less than the lung. Particle size dependence on uptake and retention was noted for the skeleton, mediastinal lymph nodes, hepatic lymph nodes, retropharyngeal lymph nodes, and mandibular lymph nodes.

• Research Organization: Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM
• OSTI ID: 6497201
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMALS
BIOLOGICAL HALF-LIFE
BODY
CHARGED PARTICLES
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
DOGS
DOSE-RESPONSE RELATIONSHIPS
EVEN-ODD NUCLEI
GLANDS
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
KIDNEYS
LIVER
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
NUCLEI
ORGANS
PARTICLE SIZE
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
RETENTION
RISK ASSESSMENT
SIZE
SKELETON
SOLS
SPLEEN
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES