The effect of isotope on the dosimetry of inhaled plutonium oxide

Conference · Tue Dec 31 00:00:00 EST 1991

OSTI ID:10108381

Hickman, A W ^[1]

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1. Florida Univ., Gainesville, FL (United States)

Results of experimental studies in which animals inhaled {sup 238}PuO{sub 2} or {sup 239}PuO{sub 2} aerosols have shown that the biokinetics and associated radiation dose patterns for these two isotopes differ significantly due to differences in in-vivo solubility caused by the 260-fold difference in specific activity between {sup 238}PuO{sub 2} and {sup 239}PuO{sub 2}. We have adapted a biokinetics and dosimetry model derived from results of the ITRI dog studies to humans and have calculated dose commitments and annual limits on intake (ALI) for both Pu isotopes. Our results show that the ALI calculated in this study is one-third that for class Y {sup 238}Pu from ICRP 30, and one-half or equal to that for class Y {sup 239}Pu, depending on how activity in the thoracic lymph nodes is treated dosimetrically.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 10108381
• Report Number(s): CONF-920501-9; ON: DE92004257
• Resource Relation: Conference: 8. International Radiation Protection Association (IRPA) world congress,Vancouver (Canada),10-22 May 1992; Other Information: PBD: [1991]
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PLUTONIUM OXIDES
INHALATION
MAN
RADIONUCLIDE KINETICS
DOGS
DOSIMETRY
ANNUAL LIMIT OF INTAKE
AEROSOLS
DOSE COMMITMENTS
LUNGS
LIVER
SKELETON
RADIOCHEMICAL ANALYSIS
560161
560162
ANIMALS, PLANTS, MICROORGANISMS, AND CELLS