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Title: Micro-radiosurgery: A new concept for radiotherapy based upon low energy, ion-induced nuclear reactions

Abstract

Traditionally, proton radiotherapy has required the use of high energy proton beams (50--200 MeV) which can penetrate into a patients body to the site of a tumor that is to be destroyed through irradiation. However, substantial damage is still done to healthy tissue along the path of the incident proton beam, as 40% of that done at the tumor site. We propose a new concept for the production and delivery of energetic protons for use in medical radiotherapy, based upon the fact that low energy, ion-induced nuclear reactions can produce radiation products suitable for use in radiotherapy applications. By employing specially fabricated ``conduit needles`` to deliver beams of energetic ions to selected target materials plugging the end of the needle, ion beam-induced nuclear reactions can be generated at the needle tip, emitting reaction-specific radiation products directly at the tumor site In this paper, we show that the 13.6 MeV protons produced by the d({sup 3}He,p){sup 4}He nuclear reaction can deliver a lethal dose (7 krad) of radiation to a 4.4 millimeter sphere of tissue in only 30 seconds using a 1 microamp, 800 keV {sup 3}He ion beam. If also proven clinically feasible, the use of low energy, ion-induced nuclearmore » reactions would allow the utilization of relatively inexpensive, compact, low-energy ion accelerators for proton radiotherapy and minimize unintended radiation damage to healthy tissue by providing much greater precision in controlling the irradiated volume.« less

Authors:
;
Publication Date:
Research Org.:
Sandia National Labs., Albuquerque, NM (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
10106469
Report Number(s):
SAND-92-2410C; CONF-921116-15
ON: DE93003995
DOE Contract Number:  
AC04-76DP00789
Resource Type:
Conference
Resource Relation:
Conference: 12. international conference on the application of accelerators in research and industry,Denton, TX (United States),2-5 Nov 1992; Other Information: PBD: [1992]
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; RADIOTHERAPY; HELIUM IONS; THERAPEUTIC USES; PROTONS; DOSIMETRY; 550603; EXTERNAL RADIATION IN THERAPY

Citation Formats

Horn, K M, and Doyle, B L. Micro-radiosurgery: A new concept for radiotherapy based upon low energy, ion-induced nuclear reactions. United States: N. p., 1992. Web.
Horn, K M, & Doyle, B L. Micro-radiosurgery: A new concept for radiotherapy based upon low energy, ion-induced nuclear reactions. United States.
Horn, K M, and Doyle, B L. 1992. "Micro-radiosurgery: A new concept for radiotherapy based upon low energy, ion-induced nuclear reactions". United States.
@article{osti_10106469,
title = {Micro-radiosurgery: A new concept for radiotherapy based upon low energy, ion-induced nuclear reactions},
author = {Horn, K M and Doyle, B L},
abstractNote = {Traditionally, proton radiotherapy has required the use of high energy proton beams (50--200 MeV) which can penetrate into a patients body to the site of a tumor that is to be destroyed through irradiation. However, substantial damage is still done to healthy tissue along the path of the incident proton beam, as 40% of that done at the tumor site. We propose a new concept for the production and delivery of energetic protons for use in medical radiotherapy, based upon the fact that low energy, ion-induced nuclear reactions can produce radiation products suitable for use in radiotherapy applications. By employing specially fabricated ``conduit needles`` to deliver beams of energetic ions to selected target materials plugging the end of the needle, ion beam-induced nuclear reactions can be generated at the needle tip, emitting reaction-specific radiation products directly at the tumor site In this paper, we show that the 13.6 MeV protons produced by the d({sup 3}He,p){sup 4}He nuclear reaction can deliver a lethal dose (7 krad) of radiation to a 4.4 millimeter sphere of tissue in only 30 seconds using a 1 microamp, 800 keV {sup 3}He ion beam. If also proven clinically feasible, the use of low energy, ion-induced nuclear reactions would allow the utilization of relatively inexpensive, compact, low-energy ion accelerators for proton radiotherapy and minimize unintended radiation damage to healthy tissue by providing much greater precision in controlling the irradiated volume.},
doi = {},
url = {https://www.osti.gov/biblio/10106469}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1992},
month = {12}
}

Conference:
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