Rigid bifunctional chelating agents

Patent · Tue Feb 08 00:00:00 EST 2000

OSTI ID:872845

Sweet, Mark P ^[1]; Mease, Ronnie C ^[2]; Srivastava, Suresh C ^[3]

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1. Coram, NY
2. Fairfax, VA
3. Setauket, NY

Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

• Research Organization: Associated Universities, Inc., Upton, NY (United States)
• DOE Contract Number: AC02-76CH00016
• Assignee: Brookhaven Science Associates (Upton, NY)
• Patent Number(s): US 6022522
• Application Number: 09/046,030
• OSTI ID: 872845
• Country of Publication: United States
• Language: English

Related Subjects

rigid
bifunctional
chelating
agents
bicyclo
octane-2
diamine-n
-tetraacetic
acids
bodta
heptane-2
acid
bhdta
useful
forming
detectably
labeled
bioconjugate
compounds
diagnostic
therapeutic
purposes
processes
disclosed
radioimmunoconjugates
prolonged
tumor
uptake
normal
tissue
uptakes
therapeutic purposes
-tetraacetic acid
bifunctional chelating
acetic acid
chelating agents
chelating agent
tumor uptake
agents useful
rigid bifunctional
normal tissue
-tetraacetic acids
forming detectably
detectably labeled
labeled bioconjugate
/424/999/