Rigid bifunctional chelating agents
Patent
·
OSTI ID:672562
Bicyclo[2.2.2] octane-2,3 diamine-N,N,N`,N`-tetraacetic acids (BODTA) and bicyclo[2.2.1] heptane-2,3 diamine-N,N,N`,N`-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.
- Research Organization:
- Associated Universities Inc
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- Brookhaven Science Associates LLC, Upton, NY (United States)
- Patent Number(s):
- US 5,783,169/A/
- Application Number:
- PAN: 8-506,889; TRN: 99:001057
- OSTI ID:
- 672562
- Resource Relation:
- Other Information: PBD: 21 Jul 1998
- Country of Publication:
- United States
- Language:
- English
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