Rigid bifunctional chelating agents

Patent · Tue Feb 08 00:00:00 EST 2000

OSTI ID:20013268

Sweet, M P; Mease, R C; Srivastava, S C

Bicyclo[2.2.2]octane-2,3 diamine-N,N,N,N{prime}-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N{prime},N{prime}-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.

• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 20013268
• Resource Relation: Other Information: PBD: 8 Feb 2000
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CHELATING AGENTS
USES
DIAGNOSIS
THERAPY
RADIOPHARMACEUTICALS
NEOPLASMS