Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)

Garimella, Sandilya V. B; Ibrahim, Yehia M.; Webb, Ian K.; Tolmachev, Aleksey V.; Zhang, Xinyu; Prost, Spencer A.; Anderson, Gordon A.; Smith, Richard D.

doi:10.1007/s13361-014-0976-y

Title: Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)

Journal Article · Fri Sep 26 00:00:00 EDT 2014 · Journal of the American Society for Mass Spectrometry

DOI:https://doi.org/10.1007/s13361-014-0976-y· OSTI ID:1166834

Garimella, Sandilya V. B ^[1]; Ibrahim, Yehia M. ^[1]; Webb, Ian K. ^[1]; Tolmachev, Aleksey V. ^[1]; Zhang, Xinyu ^[1]; Prost, Spencer A. ^[1]; Anderson, Gordon A. ^[1]; Smith, Richard D. ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division

Here we report a conceptual study and computational evaluation of novel planar electrode Structures for Lossless Ion Manipulations (SLIM). Planar electrode SLIM devices were designed that allow for flexible ion confinement, transport and storage using a combination of RF and DC fields. Effective potentials can be generated that provide near ideal regions for confining ions in the presence of a gas. Ion trajectory simulations using SIMION 8.1 demonstrated the capability for lossless ion motion in these devices over a wide m/z range and a range of electric fields at low pressures (e.g. a few torr). More complex ion manipulations, e.g. turning ions by 90° and dynamically switching selected ion species into orthogonal channels, are also feasible. Lastly, the performance of SLIM devices at ~4 torr pressure for performing ion mobility based separations (IMS) is computationally evaluated and compared to initial experimental results, and both of which agree closely with experimental and theoretical IMS performance for a conventional drift tube design.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

Grant/Contract Number:: AC05-76RL01830; P41 GM103493; R21 GM103497

OSTI ID:: 1166834

Report Number(s):: PNNL-SA-103104; 48135; 47418; 46206; 400412000

Journal Information:: Journal of the American Society for Mass Spectrometry, Vol. 25, Issue 11; ISSN 1044-0305

Publisher:: American Society for Mass SpectrometryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 41 works

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Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses Dou, Maowei; Chouinard, Christopher D.; Zhu, Ying Analytical and Bioanalytical Chemistry, Vol. 411, Issue 21 https://doi.org/10.1007/s00216-018-1452-5	journal	November 2018
Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations Chen, Tsung-Chi; Webb, Ian K.; Prost, Spencer A. Analytical Chemistry, Vol. 87, Issue 1 https://doi.org/10.1021/ac503564c	journal	December 2014

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Title: Simulation of Electric Potentials and Ion Motion in Planar Electrode Structures for Lossless Ion Manipulations (SLIM)

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