Ion manipulations in structures for lossless ion manipulations (SLIM): computational evaluation of a 90° turn and a switch

Garimella, Sandilya V.  B.; Ibrahim, Yehia. M.; Webb, Ian K.; Ipsen, Andreas B.; Chen, Tsung-Chi; Tolmachev, Aleksey V.; Baker, Erin S.; Anderson, Gordon A.; Smith, Richard D.

doi:10.1039/c5an00844a

Title: Ion manipulations in structures for lossless ion manipulations (SLIM): computational evaluation of a 90° turn and a switch

Journal Article · Wed Aug 19 00:00:00 EDT 2015 · Analyst

DOI:https://doi.org/10.1039/c5an00844a· OSTI ID:1229946

Garimella, Sandilya V. B. ^[1]; Ibrahim, Yehia. M. ^[1]; Webb, Ian K. ^[1]; Ipsen, Andreas B. ^[1]; Chen, Tsung-Chi ^[1]; Tolmachev, Aleksey V. ^[1]; Baker, Erin S. ^[1]; Anderson, Gordon A. ^[1]; Smith, Richard D. ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division

The process of redirecting ions through 90° turns and ‘tee’ switches utilizing Structures for Lossless Ion Manipulations (SLIM) was evaluated using theoretical and simulation methods at 4 Torr pressure. SIMION simulations were used to optimize and evaluate conditions for performing turns without loss of signal intensity or ion mobility resolving power. Fundamental considerations indicated that the “race track” effect during ion turns may incur only small losses to the ion mobility resolving power at 4 Torr pressure for the typical plume widths predicted in an optimized SLIM ‘tee’ switch design. The dynamic switching of ions into orthogonal channels was also evaluated using SIMION ion trajectory simulations, and achieved similar performance. Simulation results were in close agreement with experimental results and were used to refine SLIM designs and applied potentials for their use.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830; P41 GM103493

OSTI ID:: 1229946

Report Number(s):: PNNL-SA-107773; ANALAO; 48680; 48135; 400412000

Journal Information:: Analyst, Vol. 140, Issue 20; ISSN 0003-2654

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 35 works

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A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations Li, Ailin; Garimella, Sandilya V. B.; Ibrahim, Yehia M. The Analyst, Vol. 145, Issue 1 https://doi.org/10.1039/c9an01509d	journal	January 2020
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