Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Ion mobility (IM) is rapidly gaining attention for the separation and analysis of biomolecules due to the ability to distinguish the shapes of ions. However, conventional constant electric field drift tube IM separations have limited resolving power, constrained by practical limitations on the path length and maximum applied voltage. The implementation of traveling waves (TW) in IM removes the latter limitation, allowing higher resolution to be achieved using extended path lengths. Both of these can be readily obtained in Structures for Lossless Ion Manipulations (SLIM), which are fabricated from arrays of electrodes patterned on two parallel surfaces where potentials are applied to generate appropriate electric fields between the surfaces. Here we have investigated the relationship between the primary SLIM variables, such as electrode dimensions, inter-surface gap, and the applied TW voltages, that directly impact the fields experienced by ions. Ion trajectory simulations and theoretical calculations have been utilized to understand the dependence of SLIM geometry and effective electric fields on IM resolution. The variables explored impact both ion confinement and the observed IM resolution using SLIM modules.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- P41 GM103493; AC0576RL01830
- OSTI ID:
- 1430526
- Report Number(s):
- PNNL-SA-127372; PII: S1387380617303469
- Journal Information:
- International Journal of Mass Spectrometry, Vol. 430, Issue C; ISSN 1387-3806
- Publisher:
- ElsevierCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
Recommendations for reporting ion mobility Mass Spectrometry measurements
|
journal | October 2017 |
A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations
|
journal | January 2020 |
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Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM)
Characterization of Traveling Wave Ion Mobility Separations in Structures for Lossless Ion Manipulations