Method for measuring changes in light absorption of highly scattering media
Abstract
The noninvasive measurement of variations in absorption that are due to changes in concentrations of biochemically relevant compounds in tissue is important in many clinical settings. One problem with such measurements is that the pathlength traveled by the collected light through the tissue depends on the scattering properties of the tissue. It is demonstrated, using both Monte Carlo simulations and experimental measurements, that for an appropriate separation between light-delivery and light-collection fibers, the pathlength of the collected photons is insensitive to scattering parameters for the range of parameters typically found in tissue. This is important for developing rapid, noninvasive, inexpensive, and accurate methods for measuring absorption changes in tissue.
- Inventors:
-
- Los Alamos, NM
- Issue Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- OSTI Identifier:
- 874391
- Patent Number(s):
- 6381018
- Assignee:
- The Regents of the University of California (Los Alamos, NM)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- W-7405-ENG-36
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; measuring; changes; light; absorption; highly; scattering; media; noninvasive; measurement; variations; due; concentrations; biochemically; relevant; compounds; tissue; clinical; settings; measurements; pathlength; traveled; collected; depends; properties; demonstrated; monte; carlo; simulations; experimental; appropriate; separation; light-delivery; light-collection; fibers; photons; insensitive; parameters; range; typically; found; developing; rapid; inexpensive; accurate; methods; monte carlo; scattering media; highly scattering; measuring changes; noninvasive measurement; /356/600/
Citation Formats
Bigio, Irving J, Johnson, Tamara M, and Mourant, Judith R. Method for measuring changes in light absorption of highly scattering media. United States: N. p., 2002.
Web.
Bigio, Irving J, Johnson, Tamara M, & Mourant, Judith R. Method for measuring changes in light absorption of highly scattering media. United States.
Bigio, Irving J, Johnson, Tamara M, and Mourant, Judith R. Tue .
"Method for measuring changes in light absorption of highly scattering media". United States. https://www.osti.gov/servlets/purl/874391.
@article{osti_874391,
title = {Method for measuring changes in light absorption of highly scattering media},
author = {Bigio, Irving J and Johnson, Tamara M and Mourant, Judith R},
abstractNote = {The noninvasive measurement of variations in absorption that are due to changes in concentrations of biochemically relevant compounds in tissue is important in many clinical settings. One problem with such measurements is that the pathlength traveled by the collected light through the tissue depends on the scattering properties of the tissue. It is demonstrated, using both Monte Carlo simulations and experimental measurements, that for an appropriate separation between light-delivery and light-collection fibers, the pathlength of the collected photons is insensitive to scattering parameters for the range of parameters typically found in tissue. This is important for developing rapid, noninvasive, inexpensive, and accurate methods for measuring absorption changes in tissue.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2002},
month = {Tue Jan 01 00:00:00 EST 2002}
}
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