Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies
- Irvine, CA
- Rochester, NY
- Lake Forest, CA
- Costa Mesa, CA
A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.
- Research Organization:
- Univ. of California (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG03-91ER61227
- Assignee:
- The Regents of the Univeristy of California (Oakland, CA)
- Patent Number(s):
- 7,428,434
- Application Number:
- 10/191,693
- OSTI ID:
- 984515
- Country of Publication:
- United States
- Language:
- English
Improved solutions of the steady-state and the time-resolved diffusion equations for reflectance from a semi-infinite turbid medium
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journal | January 1997 |
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