V79 survival following simultaneous or sequential irradiation by 15-MeV neutrons and /sup 60/Co photons
A unique tandem source irradiation facility, composed of an intense d-T neutron source and a /sup 60/Co teletherapy unit, was used to investigate biological responses for different neutron/photon configurations. V79 Chinese hamster cells, attached as monolayers in log-phase growth, were irradiated at 37 degrees C by either 14.8-MeV neutrons, /sup 60/Co, or a mixture of 40% neutrons and 60% photons in simultaneous or sequential application. Measurements of cell survival indicate an increased effectiveness in cell killing for simultaneously administered neutrons and photons compared to that measured or predicted for sequentially applied beam modalities. An understanding of the magnitude of these interactive effects is important both for calculating accurate effective doses for neutron radiotherapy of deep-seated tumors, for which the photon component is appreciable, and for determination of environmental hazards to people occupationally exposed to mixtures of photons and neutrons.
- Research Organization:
- Department of Medical Physics, University of Wisconsin, Madison
- OSTI ID:
- 5671562
- Journal Information:
- Radiat. Res.; (United States), Vol. 95:1
- Country of Publication:
- United States
- Language:
- English
Similar Records
V79 survival following simultaneous or sequential irradiation by 14. 8-MeV neutrons and /sup 60/Co photons
Comments on ''V79 survival following simultaneous or sequential irradiation by 15-MeV neutrons and /sup 60/Co photons'' by Higgins et al. (Radiat. Res. 95, 45-56(1983))
Related Subjects
CHO CELLS
BIOLOGICAL RADIATION EFFECTS
SURVIVAL CURVES
NEUTRON BEAMS
COMPARATIVE EVALUATIONS
X RADIATION
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
MEDICAL PERSONNEL
OCCUPATIONAL SAFETY
RADIATION DOSE DISTRIBUTIONS
RADIOTHERAPY
ANIMAL CELLS
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
NUCLEON BEAMS
ODD-ODD NUCLEI
PARTICLE BEAMS
PERSONNEL
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
SAFETY
THERAPY
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)