V79 survival following simultaneous or sequential irradiation by 15-MeV neutrons and /sup 60/Co photons

Journal Article · Fri Jul 01 00:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576070· OSTI ID:5598175

Higgins, P D; DeLuca, Jr, P M; Pearson, D W; Gould, M N

A unique tandem source irradiation facility, composed of an intense d-T neutron source and a /sup 60/Co teletherapy unit, was used to investigate biological responses for different neutron/photon configurations. V79 Chinese hamster cells, attached as monolayers in log-phase growth, were irradiated at 37/sup 0/C by either 14.8-MeV neutrons, /sup 60/Co, or a mixture of 40% neutrons and 60% photons in simultaneous or sequential application. Measurements of cell survival indicate an increased effectiveness in cell killing for simultaneously administered neutrons and photons compared to that measured or predicted for sequentially applied beam modalities. An understanding of the magnitude of these interactive effects is important both for calculating accurate effective doses for neutron radiotherapy of deep-seated tumors, for which the photon component is appreciable, and for determination of environmental hazards to people occupationally exposed to mixtures of photons and neutrons.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 5598175
• Journal Information: Radiat. Res.; (United States), Vol. 95:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL KILLING
RADIOINDUCTION
CHO CELLS
BIOLOGICAL RADIATION EFFECTS
IRRADIATION DEVICES
DESIGN
RADIOTHERAPY
PLANNING
COBALT 60
FAST NEUTRONS
GAMMA RADIATION
IN VITRO
MEV RANGE 10-100
MICRODOSIMETRY
SURVIVAL CURVES
ANIMAL CELLS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COBALT ISOTOPES
DOSIMETRY
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY RANGE
FERMIONS
HADRONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MEV RANGE
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEAR MEDICINE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
THERAPY
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)