Comments on ''V79 survival following simultaneous or sequential irradiation by 15-MeV neutrons and /sup 60/Co photons'' by Higgins et al. (Radiat. Res. 95, 45-56(1983))
In a recent paper Higgins et al. reported survival data for V79 Chinese hamster cells exposed simultaneously or sequentially to 15-MeV neutrons and /sup 60/Co photons. In each case the results showed the combined modality to be more effective at cell killing than would be expected from the simple multiplication of the effects due to each radiation alone. Thus the effects of the two radiations are synergistic. In addition, simultaneous exposures yielded lower surviving fractions than sequential ones. Both these results are easy to understand, at least qualitatively, if the concepts of sublethal damage and sublethal damage repair are used. The proposition that simultaneous exposure is more effective than sequential ones thus proposition that simultaneous exposure is more effective than sequential ones thus becomes evident. Theoretical expressions have been derived also to quantify these phenomena. Higgins et al. rederive several of the equations previously obtained, however, the interpretation that they give to these equations is not appropriate. It is the purpose of this note to comment on some of these problems and offer a simple analysis and interpretation of the results based on sublethal damage repair.
- Research Organization:
- Columbia Univ., New York, NY
- DOE Contract Number:
- AC02-78EV04733
- OSTI ID:
- 6538119
- Journal Information:
- Radiat. Res.; (United States), Vol. 99:2
- Country of Publication:
- United States
- Language:
- English
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CELL KILLING
RADIOINDUCTION
FAST NEUTRONS
SYNERGISM
FIBROBLASTS
BIOLOGICAL RADIATION EFFECTS
GAMMA RADIATION
COBALT 60
HAMSTERS
MEV RANGE 10-100
SURVIVAL CURVES
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY RANGE
FERMIONS
HADRONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEV RANGE
MINUTES LIVING RADIOISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)