INVESTIGATION OF DRUG RELEASE FROM BIODEGRADABLE PLG MICROSPHERES: EXPERIMENT AND THEORY

Conference · Tue Jan 30 00:00:00 EST 2007

OSTI ID:985891

ANDREWS, MALCOLM J ^[1]; BERCHANE, NADER S ^[1]; CARSON, KENNETH H ^[1]; RICE-FICHT, ALLISON C ^[1]

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1. Los Alamos National Laboratory

Piroxicam containing PLG microspheres having different size distributions were fabricated, and in vitro release kinetics were determined for each preparation. Based on the experimental results, a suitable mathematical theory has been developed that incorporates the effect of microsphere size distribution and polymer degradation on drug release. We show from in vitro release experiments that microsphere size has a significant effect on drug release rate. The initial release rate decreased with an increase in microsphere size. In addition, the release profile changed from first order to concave-upward (sigmoidal) as the system size was increased. The mathematical model gave a good fit to the experimental release data.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE National Nuclear Security Administration (NNSA)
• DOE Contract Number: AC52-06NA25396
• OSTI ID: 985891
• Report Number(s): LA-UR-07-0642; TRN: US201017%%69
• Resource Relation: Conference: ASME SUMMER BIO-ENGINEERING CONFERENCE 2007 ; 200706 ; KEYSTONE
• Country of Publication: United States
• Language: English

Related Subjects

56
DISTRIBUTION
IN VITRO
KINETICS
MATHEMATICAL MODELS
MICROSPHERES
POLYMERS