Novel SERS materials for multiplex biomolecular detection via controlled nanoparticle linking and polymer encapsulation
Over the past decade the emphasis on single-molecule sensitivity of surface-enhanced Raman spectroscopy (SERS) has brought to prominence the special role played by so-called SERS 'hot spots', oftentimes nanometer-scale junctions between nanostructures. In this report, optimally SERS enhancing silver clusters were synthesized using bifunctional linkers and polymer and/or protein encapsulation. The synthesis, which results in stable clusters even when stored for months or dried and re-dissolved, is scalable to large quantities. Using a sacrificial linker approach we also employ a permeable polymer/protein shell for general small molecule sensing. Finally, we utilize these nanomaterials by tagging specific epitopes on cancer cells and show that SERS signals from single clusters can be measured routinely.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 965082
- Report Number(s):
- LLNL-JRNL-405971; TRN: US200919%%453
- Journal Information:
- Journal of Physical Chemistry. C, Vol. 113; ISSN 1932-7447
- Country of Publication:
- United States
- Language:
- English
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