Accommodating subject and instrument variations in spectroscopic determinations

Haas, Michael J; Rowe, Robert K; Thomas, Edward V

Title: Accommodating subject and instrument variations in spectroscopic determinations

Patent · Tue Aug 29 00:00:00 EDT 2006

OSTI ID:908262

Haas, Michael J ^[1]; Rowe, Robert K ^[2]; Thomas, Edward V ^[1]

Albuquerque, NM
Corrales, NM

A method and apparatus for measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved instrument-tailored or subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate instrument-specific attributes, resulting in a calibration data set modeling intra-instrument or intra-subject variation. In a prediction phase, the prediction process is tailored for each target instrument separately using a minimal number of spectral measurements from each instrument or subject.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC04-94AL85000

Assignee:: InLight Solutions, Inc. (Albuquerque, NM)

Patent Number(s):: 7,098,037

Application Number:: 10/222,721

OSTI ID:: 908262

Country of Publication:: United States

Language:: English

References (32)

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