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Title: Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders

Patent ·
OSTI ID:873984
 [1];  [1]
  1. Berkeley, CA
+ Show Author Affiliations

The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
DOE Contract Number:
AC03-76SF00098
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 6287790
OSTI ID:
873984
Country of Publication:
United States
Language:
English

References (3)

Core filaments of the nuclear matrix. journal March 1990
Human-specific nuclear protein that associates with the polar region of the mitotic apparatus: Distribution in a human/hamster hybrid cell journal November 1980
Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. journal March 1992

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Related Subjects

utilization
nuclear
structural
proteins
targeted
therapy
detection
proliferative
differentiation
disorders
localization
apparatus
numa
identify
tumor
cells
stages
progression
processes
characteristic
organization
phenotypically
normal
distribution
patterns
significantly
diffuse
proliferating
non-malignant
compared
malignant
technique
encompasses
cell
immunostaining
specific
antibody
microscopic
analysis
nucleus
normal cells
tumor cells
malignant cells
structural protein
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