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Title: Amplifications of chromosomal region 20q13 as a prognostic indicator breast cancer

Patent ·
OSTI ID:873897

The present invention relates to in situ hybridization methods for the identification of new chromosomal abnormalities associated with various diseases. In particular, it provides probes which are specific to a region of amplification in chromosome 20.

Research Organization:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
DOE Contract Number:
W-7405-ENG-48
Assignee:
Regents of University of California (Oakland, CA)
Patent Number(s):
US 6268184
OSTI ID:
873897
Country of Publication:
United States
Language:
English

References (22)

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries journal November 1988
An Expression Profile of Active Genes in Human Colonic Mucosa journal January 1994
λ ZAP: a bacteriophage λ expression vector with in vivo excision properties journal January 1988
Complete characterization of a large marker chromosome by reverse and forward chromosome painting journal December 1992
Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia journal August 1991
A single gene and a pseudogene for the cellular tumour antigen p53 journal December 1983
Analytical strategies for the use of DNA probes journal February 1988
Translocations between two specific human chromosomes detected by three-color “chromosome painting” journal January 1993
Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe journal February 1993
Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. journal December 1988
Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus journal March 1994
Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors journal October 1992
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. journal March 1994
High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones journal January 1990
In situ hybridisation with fluoresceinated DNA journal January 1991
The human glucocerebrosidase gene and pseudogene: Structure and evolution journal January 1989
Characterization of a large population of mRNAs from human testis journal March 1995
Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinoma journal May 1991
A physical map of chromosome 20 established using fluorescence in situ hybridization and digital image analysis journal March 1995
The 1993–94 Généthon human genetic linkage map journal June 1994
ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. journal June 1992
Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes journal November 1988