Method for measuring lead concentrations in blood

Nogar, Nicholas S

Title: Method for measuring lead concentrations in blood

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:873797

Nogar, Nicholas S ^[1]

Los Alamos, NM

Method for measuring lead concentrations in blood. The present invention includes the use of resonant laser ablation to analyze .ltoreq.1 .mu.L (or equivalent mass) samples of blood for lead content. A typical finger prick, for example, yields about 10 .mu.L. Solid samples may also readily be analyzed by resonant laser ablation. The sample is placed on a lead-free, electrically conducting substrate and irradiated with a single, focused laser beam which simultaneously vaporizes, atomizes, and resonantly ionizes an analyte of interest in a sample. The ions are then sorted, collected and detected using a mass spectrometer.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

DOE Contract Number:: W-7405-ENG-36

Assignee:: Regents of University of California (Los Alamos, MX)

Patent Number(s):: US 6248592

OSTI ID:: 873797

Country of Publication:: United States

Language:: English

References (15)

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Laser desorption mass spectrometry of nonvolatiles under shock wave conditions Lindner, Buko.; Seydel, Ulrich. Analytical Chemistry, Vol. 57, Issue 4 https://doi.org/10.1021/ac00281a027	journal	April 1985
Resonant laser ablation—a novel surface analytic technique Borthwick, I. S.; Ledingham, K. W. D.; Singhal, R. P. Spectrochimica Acta Part B: Atomic Spectroscopy, Vol. 47, Issue 11 https://doi.org/10.1016/0584-8547(92)80117-Y	journal	October 1992
Resonant Laser Ablation: Semiquantitative Aspects and Threshold Effects Eiden, G. C.; Anderson, J. E.; Nogar, N. S. Microchemical Journal, Vol. 50, Issue 3 https://doi.org/10.1006/mchj.1994.1095	journal	December 1994
LAMMA 500 principle and technical description of the instrument Vogt, H.; Heinen, H. J.; Meier, S. Fresenius' Zeitschrift für analytische Chemie, Vol. 308, Issue 3 https://doi.org/10.1007/BF00479623	journal	January 1981
Chromium detection by laser desorption and resonance ionization mass spectrometry Nogar, N. S.; Estler, R. C. Analytical Chemistry, Vol. 64, Issue 5 https://doi.org/10.1021/ac00029a003	journal	March 1992
Direct determination of lead in blood by laser-excited flame atomic-fluorescence spectrometry Omenetto, Nicolo; Human, Hendricks G. C.; Cavalli, Paulo The Analyst, Vol. 109, Issue 8 https://doi.org/10.1039/an9840901067	journal	January 1984
Sample preparation technique for the analysis of vegetative bacteria cells of the genus bacillus with the laser microprobe mass analyzer (LAMMA) Böhm, R. Fresenius' Zeitschrift für analytische Chemie, Vol. 308, Issue 3 https://doi.org/10.1007/BF00479636	journal	January 1981
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The distribution of lead in human hemopoietic tissue and spongy bone after lead poisoning and Ca-EDTA chelation therapy: Observations made by atomic absorption spectroscopy, laser microbeam mass analysis and electron microbeam X-ray analysis Flood, Per R.; Schmidt, Peter Fritz; Wesenberg, Gro R. Archives of Toxicology, Vol. 62, Issue 4 https://doi.org/10.1007/BF00332490	journal	October 1988
Multi-elemental analysis of environmental matrices by laser ablation inductively coupled plasma mass spectrometry Durrant, Steven F. The Analyst, Vol. 117, Issue 10 https://doi.org/10.1039/an9921701585	journal	January 1992
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Related Subjects

method
measuring
lead
concentrations
blood
resonant
laser
ablation
analyze
ltoreq
equivalent
mass
samples
content
typical
finger
prick
example
yields
10
solid
readily
analyzed
sample
placed
lead-free
electrically
conducting
substrate
irradiated
single
focused
beam
simultaneously
vaporizes
atomizes
resonantly
ionizes
analyte
sorted
collected
detected
spectrometer
focused laser
solid sample
mass spectrometer
laser beam
electrically conducting
laser ablation
measuring lead
resonant laser
lead content
conducting substrate
lead concentrations
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Title: Method for measuring lead concentrations in blood

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References (15)

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