Pyrrolo isoquinolines

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:873450

Goodman, Mark M ^[1]; Shi, Bing Z ^[2]

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1. Atlanta, GA
2. Cincinnati, OH

Compounds of the formula: ##STR1## wherein X, Y, and R, independently of one another, is each a H; halogen, wherein said halogen is selected from the group consisting of .sup.123 I, .sup.124 I, .sup.125 I, .sup.131 I, .sup.75 Br, .sup.76 Br, .sup.77 Br, .sup.82 Br, .sup.18 F, or .sup.210 At; small alkyl, small alkenyl, or small alkynyl, any of which contains from one to about six carbon atoms and optionally having a carbon atom replaced by an O or S; or halogen substituted-small alkyl, halogen substituted-small alkenyl, or halogen substituted-small alkynyl wherein said compound contains at least one radioacitve halogen. The compounds bind to the serotonin transporter. Depending upon the choice of halogen substituent, the compounds are useful for PET or SPECT imaging, diagnosis and treatment of psychiatric disorders such as depression, anxiety, obsessive-compulsive disorder, and other conditions associated with defects of serotonin transporter function.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
• DOE Contract Number: AC04-76
• Assignee: Emory University (Atlanta, GA)
• Patent Number(s): US 6162417
• OSTI ID: 873450
• Country of Publication: United States
• Language: English

Related Subjects

pyrrolo
isoquinolines
compounds
formula
str1
independently
halogen
selected
consisting
123
124
125
131
75
br
76
77
82
18
210
alkyl
alkenyl
alkynyl
contains
six
carbon
atoms
optionally
atom
replaced
substituted-small
compound
radioacitve
bind
serotonin
transporter
depending
choice
substituent
useful
pet
spect
imaging
diagnosis
treatment
psychiatric
disorders
depression
anxiety
obsessive-compulsive
disorder
conditions
associated
defects
function
serotonin transporter
carbon atoms
carbon atom
compound contains
/424/999/