Human jagged polypeptide, encoding nucleic acids and methods of use
- Seattle, WA
The present invention provides an isolated polypeptide exhibiting substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the polypeptide does not have the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. The invention further provides an isolated nucleic acid molecule containing a nucleotide sequence encoding substantially the same amino acid sequence as JAGGED, or an active fragment thereof, provided that the nucleotide sequence does not encode the amino acid sequence of SEQ ID NO:5 or SEQ ID NO:6. Also provided herein is a method of inhibiting differentiation of hematopoietic progenitor cells by contacting the progenitor cells with an isolated JAGGED polypeptide, or active fragment thereof. The invention additionally provides a method of diagnosing Alagille Syndrome in an individual. The method consists of detecting an Alagille Syndrome disease-associated mutation linked to a JAGGED locus.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- DOE Contract Number:
- AC03-76SF00098
- Assignee:
- University of Washington (Seattle, WA)
- Patent Number(s):
- US 6136952
- OSTI ID:
- 873333
- Country of Publication:
- United States
- Language:
- English
Similar Records
Nucleic Acid Encoding A Lectin-Derived Progenitor Cell Preservation Factor
Nucleic acids encoding antifungal polypeptides and uses thereof
Related Subjects
jagged
polypeptide
encoding
nucleic
acids
methods
provides
isolated
exhibiting
substantially
amino
acid
sequence
active
fragment
provided
seq
molecule
containing
nucleotide
encode
method
inhibiting
differentiation
hematopoietic
progenitor
cells
contacting
additionally
diagnosing
alagille
syndrome
individual
consists
detecting
disease-associated
mutation
linked
locus
acid molecule
method consists
molecule containing
nucleotide sequence
acid sequence
amino acid
nucleic acid
nucleic acids
sequence encoding
isolated polypeptide
/530/435/999/