Method for obtaining chromosome painting probes

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:873314

Lucas, Joe N ^[1]

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1. San Ramon, CA

A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 6132974
• OSTI ID: 873314
• Country of Publication: United States
• Language: English

Related Subjects

method
obtaining
chromosome
painting
probes
provided
determining
clastogenic
signature
sample
chromosomes
quantifying
frequency
type
aberration
comparing
identify
agent
dosage
cells
exposed
clastogenic signature
chromosome aberration
clastogenic agent
chromosome painting
/435/436/999/