Neutron capture therapies
- Cambridge, MA
- Newton, MA
- Winchester, MA
In one embodiment there is provided an application of the .sup.10 B(n,.alpha.).sup.7 Li nuclear reaction or other neutron capture reactions for the treatment of rheumatoid arthritis. This application, called Boron Neutron Capture Synovectomy (BNCS), requires substantially altered demands on neutron beam design than for instance treatment of deep seated tumors. Considerations for neutron beam design for the treatment of arthritic joints via BNCS are provided for, and comparisons with the design requirements for Boron Neutron Capture Therapy (BNCT) of tumors are made. In addition, exemplary moderator/reflector assemblies are provided which produce intense, high-quality neutron beams based on (p,n) accelerator-based reactions. In another embodiment there is provided the use of deuteron-based charged particle reactions to be used as sources for epithermal or thermal neutron beams for neutron capture therapies. Many d,n reactions (e.g. using deuterium, tritium or beryllium targets) are very prolific at relatively low deuteron energies.
- Research Organization:
- Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Newton Scientific, Inc. (Cambridge, MA)
- DOE Contract Number:
- FG02-89ER60874
- Assignee:
- Massachusetts Institute of Technology (Cambridge, MA); Newton Scientific, Inc. (Cambridge, MA)
- Patent Number(s):
- US 5976066
- OSTI ID:
- 872624
- Country of Publication:
- United States
- Language:
- English
Accelerator-based Epithermal Neutron Sources for Boron Neutron Capture Therapy of Brain Tumors
|
journal | March 2003 |
Accelerator-based epithermal neutron beam design for neutron capture therapy
|
journal | May 1992 |
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Related Subjects
capture
therapies
embodiment
provided
application
10
alpha
nuclear
reaction
reactions
treatment
rheumatoid
arthritis
called
boron
synovectomy
bncs
requires
substantially
altered
demands
beam
design
instance
deep
seated
tumors
considerations
arthritic
joints
via
comparisons
requirements
therapy
bnct
addition
exemplary
moderator
reflector
assemblies
produce
intense
high-quality
beams
based
accelerator-based
deuteron-based
charged
particle
sources
epithermal
thermal
deuterium
tritium
beryllium
targets
prolific
relatively
deuteron
energies
thermal neutron
neutron capture
charged particle
boron neutron
capture therapy
nuclear reaction
neutron beam
neutron beams
rheumatoid arthritis
capture reactions
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