Comparison of rats and dogs exposed to /sup 239/PuO/sub 2/
Rats and dogs inhaled aerosols of /sup 239/PuO/sub 2/ at comparable ages relative to their lifespan. Both received a single exposure. The estimated lung doses at death in dogs were between 1100 and 11,000 rad. From two inhalation experiments, rats receiving doses in this range were chosen from the high-level exposed animals for comparison. Based on this data base, several comparisons were investigated. Metabolism of the material was compared for all animals and for animals which developed lung tumors. The differences in histopathology and tumor incidence in the lung were also reviewed. Although there were several differences between species, there were also many similarities. On-going research in dogs should produce data which will allow clarification of these relationships.
- Research Organization:
- Battelle Pacific Northwest Labs., Richland, WA (USA)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 6983609
- Report Number(s):
- PNL-SA-8091; CONF-791077-6; TRN: 81-003309
- Resource Relation:
- Conference: Workshop on measurement and interpretation of actinide accumulation by man, Snowbird, UT, USA, 14 Oct 1979
- Country of Publication:
- United States
- Language:
- English
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COMPARATIVE EVALUATIONS
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560162* - Radionuclide Effects
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