Mutagenicity testing of energy-related compounds. [Chemical effluents from coal conversion processes]
To rapidly determine the potential biohazards (mutagenicity) of various crude and complex test materials derived from fossil fuel conversion activities, the feasibility of using short-term genetic assays to predict, isolate, and identify the chemical hazards. The biological screening assay using the Salmonella-mammalian microsome method was coupled to an analytical chemistry separation procedure so that the chemical work and priorities for identification could be determined by the bioassay. It was concluded that the detection of mutagenic activity may well be a function of the chemical fractionation scheme utilized. The inability to recover specific chemical classes or the formation of artifacts by the treatment could well distort the results obtained, as could an inability to detect the specific biological end point chosen.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6639333
- Report Number(s):
- CONF-780668-1
- Resource Relation:
- Conference: Conference on energy and health, Alto, UT, USA, 26 Jun 1978
- Country of Publication:
- United States
- Language:
- English
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