Mixed ligand chelate therapy for plutonium and toxic metals from energy power production. Final report, April 15, 1977-October 14, 1980. [Mice]

Technical Report · Tue Oct 14 00:00:00 EDT 1980

DOI:https://doi.org/10.2172/6394819· OSTI ID:6394819

Schubert, J

The results of experiments are summarized on the ability of combinations of chelating agents to modify the genotoxicity or tissue distributions. The mutagenicities of Cr and of chelating agents were determined. The metals described in the report are Pu(IV), Cd(II), Cr(III), and Cr(VI). Accurate measurements were made of the ability of CaNa/sub 2/EDTA, CaNa/sub 3/DTPA, and DMPS to reduce mortality in mice given doses (i.p.) of CdCl/sub 2/ well above the 100% lethal level. The efficacy in terms of the mmoles/kg needed to reduce the mortality was: DTPA > EDTA > DMPS. The combination of DTPA + DMPS proved most promising though little evidence for mixed complex formation was noted. Potentiometric titration studies the case of Pu(IV) a few combinations proved effective, but only when given shortly after Pu administration and then only in the liver but not the skeleton. It is recommended that metabolically stable chelating agents be used in combinations, especially for those combinations which may form very stable mixed ligand chelates.

• Research Organization: Hope Coll., Holland, MI (USA). Div. of Natural Sciences
• DOE Contract Number: AS02-77EV04369
• OSTI ID: 6394819
• Report Number(s): DOE/EV/04369-T1; COO-4369-3; TRN: 81-009618
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
MUTAGENESIS
TISSUE DISTRIBUTION
CHELATING AGENTS
BIOLOGICAL EFFECTS
CHROMIUM
PLUTONIUM
THERAPY
COMPARATIVE EVALUATIONS
DECONTAMINATION
DTPA
EDTA
EXCRETION
METABOLISM
MICE
MORTALITY
TOXICITY
ACTINIDES
AMINO ACIDS
ANIMALS
CARBOXYLIC ACIDS
CLEANING
CLEARANCE
DISTRIBUTION
DRUGS
ELEMENTS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRANSITION ELEMENTS
TRANSURANIUM ELEMENTS
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)