Bovine lymphocytic leukemia: studies of etiology, pathogenesis, and mode of transmission. Progress report No. 19, June 1978-June 1979

Technical Report · Sun Jul 01 00:00:00 EDT 1979

DOI:https://doi.org/10.2172/6009642· OSTI ID:6009642

Sorensen, D. K.

Bovine leukemia is believed to be caused by an oncogenic RNA virus designated bovine leukemia virus (BLV). The presence of BLV particles in lymphocyte cultures from leukemic cattle and cattle with a persistent lymphocytosis has been consistentily demonstrated. Concentrated, cell free, BLV preparations were used to inoculate 12 late stage bovine fetuses (in utero) and two newborn calves. Current studies involve extensive monitoring of these inoculated animals to detect precancerous changes and obtain a detailed description of the events preceding the development of lymphosarcoma. Ongoing monitoring studies will provide a complete record of all changes in the various leukemia associated parameters. We will then be able to detail when, in what sequence, and to what extent each parameter changes in the course of lymphosarcoma development. Fourteen animals were successfully inoculated during the study. Eleven remain alive, and comprise the current monitoring program. All eleven of these animals are definitely infected with BLV, and in nine the infection has substantially progressed with respect to the parameters being monitored. In addition to transmission and monitoring studies, various lymphocyte subpopulations were examined to determine which cell type(s) are involved in the pathogenesis of bovine lymphosarcoma. These studies have conclusively established that B-lymphocytes are the target cells for BLV infection and that they carry the morphologic nuclear abnormality associated with this disease.

• Research Organization: Minnesota Univ., St. Paul (USA). Coll. of Veterinary Medicine
• DOE Contract Number: EY-76-S-02-0910
• OSTI ID: 6009642
• Report Number(s): COO-0910-48
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LEUKEMIA
ETIOLOGY
PATHOGENESIS
LEUKEMIA VIRUSES
BIOLOGICAL EFFECTS
LYMPHOCYTES
ONCOGENIC TRANSFORMATIONS
LYMPHOSARCOMAS
COWS
EXPERIMENTAL DATA
ISOLATED VALUES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CATTLE
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DOMESTIC ANIMALS
HEMIC DISEASES
INFORMATION
LEUKOCYTES
LYMPHOMAS
MAMMALS
MICROORGANISMS
NEOPLASMS
NUMERICAL DATA
ONCOGENIC VIRUSES
PARASITES
RUMINANTS
SARCOMAS
SOMATIC CELLS
VERTEBRATES
VIRUSES
550900* - Pathology