Emission computed tomography of /sup 18/F-fluorodeoxyglucose and /sup 13/N-ammonia in stroke and epilepsy
The ECAT Positron Tomograph was used to scan normal control subjects, stroke patients at various times during recovery, and patients with partial epilepsy during EEG monitoring. /sup 18/F-fluorodeoxyglucose (/sup 18/FDG) and /sup 13/N-Ammonia (/sup 13/NH/sub 3/) were used as indicators of abnormalities in local cerebral glucose utilization (LCMR/sub glc/) and relative perfusion, respectively. Hypometabolism, due to deactivation or minimal damage, was demonstrated with the /sup 18/FDG scan in deep structures and broad zones of cerebral cortex which appeared normal on x-ray CT (XCT) and /sup 99m/Tc pertechnetate scans. In patients with partial epilepsy, who had unilateral or focal electrical abnormalities, interictal /sup 18/FDG scan patterns clearly showed localized regions of decreased (20 to 50%) LCMR/sub glc/, which correlated anatomically with the eventual EEG localization.
- Research Organization:
- California Univ., Los Angeles (USA). Lab. of Nuclear Medicine and Radiation Biology
- DOE Contract Number:
- AC03-76SF00012
- OSTI ID:
- 5180099
- Report Number(s):
- UCLA-12-1259; CONF-800937-1; TRN: 80-014809
- Resource Relation:
- Conference: International symposium on medical radionuclide imaging, Heidelburg, F.R. Germany, 1 Sep 1980
- Country of Publication:
- United States
- Language:
- English
Similar Records
Imaging local brain function with emission computed tomography
Epilepsy
Related Subjects
BRAIN
ECAT SCANNING
GLUCOSE
METABOLISM
AMMONIA
EPILEPSY
FLUORINE 18
NITROGEN 13
PATHOLOGICAL CHANGES
POSITRON COMPUTED TOMOGRAPHY
VASCULAR DISEASES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
HYDRIDES
HYDROGEN COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOTON EMISSION SCANNING
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
550501* - Metabolism- Tracer Techniques
550901 - Pathology- Tracer Techniques