Short-term bioassay of complex organic mixtures. Part II. Mutagenicity testing
The feasibility of using short-term mutagenicity assays to predict the potential biohazard of various crude and complex test materials has been examined in a coupled chemical and biological approach. The principal focus of the research has involved the preliminary chemical characterizatiion and preparation for bioassay, followed by testing in the Salmonella histidine reversion assay system. The mutagenicity tests are intended to act as predictors of profound long-range health effects such as mutagenesis and/or carcinogenesis; act as a mechanism to rapidly isolate and identify a hazardous agent in a complex mixture; and function as a measure of biological activity correlating baseline data with changes in process conditions. Since complex mixtures can be fractionated and approached in these short-term assays, information reflecting on the actual compounds responsible for the biological effect may be accumulated.
- Research Organization:
- Oak Ridge National Lab., Tenn. (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5133896
- Report Number(s):
- CONF-780227-2
- Resource Relation:
- Conference: Symposium on application of short-term bioassays in the fractionation and analysis of complex environmental mixtures, Williamsburg, VA, USA, 21 Feb 1978
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HAZARDOUS MATERIALS
BIOASSAY
ORGANIC COMPOUNDS
BIOLOGICAL EFFECTS
FRACTIONATION
SALMONELLA
MUTAGENESIS
CHEMICAL COMPOSITION
BACTERIA
MICROORGANISMS
SEPARATION PROCESSES
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)