Total internal reflection enabled wide-field Coherent anti-Stokes Raman scattering microscopy

Doughty, Benjamin L.; Ma, Yingzhong

Title: Total internal reflection enabled wide-field Coherent anti-Stokes Raman scattering microscopy

Patent · Tue Mar 14 00:00:00 EDT 2023

OSTI ID:1987220

Doughty, Benjamin L.; Ma, Yingzhong

A system is provided. The system has a femtosecond oscillator to generate pulses used for pump and probe beams. A photonic crystal fiber is disposed in a path of the probe beam and produces pulses for a chirped probe beam. A high NA objective receives the pump and the chirped probe beam, redirects the received beams through a dielectric substrate towards an interface between a sample and the dielectric substrate to cause total internal reflection (TIR) at the sample-substrate interface, and produces corresponding evanescent waves in a portion of the sample adjacent to the sample-substrate interface, and collects a backward-propagating beam of pulses of responsive light. The portion of the sample illuminated by the evanescent waves emits responsive light. The dielectric substrate is transparent to the responsive light, the pump and the chirped probe beam. An image is produced having a specific image size using the received backward-propagating beam.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle LLC (Oak Ridge, TN)

Patent Number(s):: 11,604,144

Application Number:: 17/240,514

OSTI ID:: 1987220

Resource Relation:: Patent File Date: 04/26/2021

Country of Publication:: United States

Language:: English

References (30)

Wide-field coherent anti-Stokes Raman scattering microscopy based on picosecond supercontinuum source Shen, Yujie; Wang, Jizhou; Wang, Kai APL Photonics, Vol. 3, Issue 11 https://doi.org/10.1063/1.5045575	journal	November 2018
Imaging properties of surface-enhanced coherent anti-Stokes Raman scattering microscopy on thin gold films Kenison, John P.; Fast, Alexander; Guo, Facheng Journal of the Optical Society of America B, Vol. 34, Issue 10 https://doi.org/10.1364/JOSAB.34.002104	journal	January 2017
Elucidation of Perovskite Film Micro-Orientations Using Two-Photon Total Internal Reflectance Fluorescence Microscopy Watson, Brianna R.; Yang, Bin; Xiao, Kai The Journal of Physical Chemistry Letters, Vol. 6, Issue 16 https://doi.org/10.1021/acs.jpclett.5b01474	journal	July 2015
Multi-focus excitation coherent anti-Stokes Raman scattering (CARS) microscopy and its applications for real-time imaging Minamikawa, Takeo; Hashimoto, Mamoru; Fujita, Katsumasa Optics Express, Vol. 17, Issue 12 https://doi.org/10.1364/OE.17.009526	journal	May 2009
Raman chemical imaging of the rhizosphere bacterium Pantoea sp. YR343 and its co-culture with Arabidopsis thaliana Polisetti, Sneha; Bible, Amber N.; Morrell-Falvey, Jennifer L. The Analyst, Vol. 141, Issue 7 https://doi.org/10.1039/C6AN00080K	journal	January 2016
Total Internal Reflection Fluorescence (TIRF) Microscopy Fish, Kenneth N. Current Protocols in Cytometry, Vol. 50, Issue 1 https://doi.org/10.1002/0471142956.cy1218s50	journal	October 2009
Wide-field coherent anti-Stokes Raman scattering microscopy Heinrich, Christoph; Bernet, Stefan; Ritsch-Marte, Monika Applied Physics Letters, Vol. 84, Issue 5 https://doi.org/10.1063/1.1641164	journal	February 2004
Surface-enhanced coherent anti-Stokes Raman imaging of lipids Fast, Alexander; Kenison, John P.; Syme, Christopher D. Applied Optics, Vol. 55, Issue 22 https://doi.org/10.1364/AO.55.005994	journal	January 2016
High-speed polarization-resolved coherent Raman scattering imaging Hofer, Matthias; Balla, Naveen K.; Brasselet, Sophie Optica, Vol. 4, Issue 7 https://doi.org/10.1364/OPTICA.4.000795	journal	January 2017
Light Source Apparatus and Information Acquisition Apparatus Including the Same Inoue, Yukihiro; Iwase, Hideo https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20150354940 US Patent Application 14/724434; 20150354940	patent-application	December 2015
Selective imaging of saturated and unsaturated lipids by wide-field CARS-microscopy Heinrich, Christoph; Hofer, Alexander; Ritsch, Andreas Optics Express, Vol. 16, Issue 4 https://doi.org/10.1364/OE.16.002699	journal	January 2008
Wide-field vibrational phase imaging in an extremely folded box-CARS geometry Berto, Pascal; Jesacher, Alexander; Roider, Clemens Optics Letters, Vol. 38, Issue 5 https://doi.org/10.1364/OL.38.000709	journal	January 2013
Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine Evans, Conor L.; Xie, X. Sunney Annual Review of Analytical Chemistry, Vol. 1, Issue 1 https://doi.org/10.1146/annurev.anchem.1.031207.112754	journal	July 2008
Ultrafast, Multiphoton-Pump, Multiphoton-Probe Spectroscopy Morrow, Darien James; Kohler, Daniel David; Wright, John Curtis https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20190391070 US Patent Application 16/446750; 20190391070	patent-application	December 2019
Energetics at the Surface: Direct Optical Mapping of Core and Surface Electronic Structure in CdSe Quantum Dots Using Broadband Electronic Sum Frequency Generation Microspectroscopy Watson, Brianna R.; Doughty, Benjamin; Calhoun, Tessa R. Nano Letters, Vol. 19, Issue 9 https://doi.org/10.1021/acs.nanolett.9b02201	journal	August 2019
High-speed coherent Raman fingerprint imaging of biological tissues Camp Jr, Charles H.; Lee, Young Jong; Heddleston, John M. Nature Photonics, Vol. 8, Issue 8 https://doi.org/10.1038/nphoton.2014.145	journal	July 2014
Methods and Systems for Coherent Raman Scattering Freudiger, Christian Wilhelm; Trautman, Jay Kenneth https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20160178439 US Patent Application 14/99533; 20160178439	patent-application	June 2016
Vibrational spectra and assignment of acetone, ααα acetone-d3 and acetone-d6 Dellepiane, Giovanna; Overend, J. Spectrochimica Acta, Vol. 22, Issue 4 https://doi.org/10.1016/0371-1951(66)80091-7	journal	April 1966
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy Evans, C. L.; Potma, E. O.; Puoris'haag, M. Proceedings of the National Academy of Sciences, Vol. 102, Issue 46 https://doi.org/10.1073/pnas.0508282102	journal	November 2005
A wide-field arrangement for single-shot CARS imaging of living cells: A wide-field arrangement for single-shot CARS imaging of living cells Silve, A.; Dorval, N.; Schmid, T. Journal of Raman Spectroscopy, Vol. 43, Issue 5 https://doi.org/10.1002/jrs.4051	journal	April 2012
Label-Free Non-linear Multimodal Optical Microscopy—Basics, Development, and Applications Mazumder, Nirmal; Balla, Naveen K.; Zhuo, Guan-Yu Frontiers in Physics, Vol. 7 https://doi.org/10.3389/fphy.2019.00170	journal	October 2019
On illumination schemes for wide-field CARS microscopy Toytman, I.; Simanovskii, D.; Palanker, D. Optics Express, Vol. 17, Issue 9 https://doi.org/10.1364/OE.17.007339	journal	January 2009
Video-rate wide-field coherent anti-Stokes Raman scattering microscopy with collinear nonphase-matching illumination Lei, Ming Journal of Biomedical Optics, Vol. 16, Issue 2 https://doi.org/10.1117/1.3533707	journal	February 2011
Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator Pegoraro, Adrian F.; Ridsdale, Andrew; Moffatt, Douglas J. Optics Express, Vol. 17, Issue 4 https://doi.org/10.1364/OE.17.002984	journal	January 2009
Light Measuring Apparatus Hirai, Kakuro https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20190154583 US Patent Application 16/163600; 20190154583	patent-application	May 2019
Broadband CARS spectral phase retrieval using a time-domain Kramers–Kronig transform Liu, Yuexin; Lee, Young Jong; Cicerone, Marcus T. Optics Letters, Vol. 34, Issue 9 https://doi.org/10.1364/OL.34.001363	journal	January 2009
Total Internal Reflection Transient Absorption Microscopy: An Online Detection Method for Microfluidics Colon, Brandon A.; Hassan, Muhammad Redwan; Saleheen, Amirus The Journal of Physical Chemistry A, Vol. 124, Issue 20 https://doi.org/10.1021/acs.jpca.9b12046	journal	April 2020
Optical Parametric Amplification of Weak Signals for Imaging Biological Tissue Boppart, Stephen A.; Zhao, Youbo https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140333925 US Patent Application 14/157840; 20140333925	patent-application	November 2014
Spectroscopic investigation of indole-3-acetic acid interaction with iron(III) Kamnev, A. A.; Shchelochkov, A. G.; Perfiliev, Yu. D. Journal of Molecular Structure, Vol. 563-564 https://doi.org/10.1016/S0022-2860(00)00911-X	journal	May 2001
Wide-field coherent anti-Stokes Raman scattering microscopy with non-phase-matching illumination Toytman, I.; Cohn, K.; Smith, T. Optics Letters, Vol. 32, Issue 13 https://doi.org/10.1364/OL.32.001941	journal	January 2007

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