Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites

Church, George M.; Raman, Srivatsan; Taylor, Noah D.; Rogers, Jameson K.

Title: Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites

Patent · Tue Mar 14 00:00:00 EDT 2023

OSTI ID:1987218

Church, George M.; Raman, Srivatsan; Taylor, Noah D.; Rogers, Jameson K.

The present invention relates to genetically modified bacteria and methods of optimizing genetically modified bacteria for the production of a metabolite.

View Patent

Cite

Export

Save

Research Organization:: Harvard Univ., Cambridge, MA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-02ER63445

Assignee:: President and Fellows of Harvard College (Cambridge, MA)

Patent Number(s):: 11,603,528

Application Number:: 16/718,736

OSTI ID:: 1987218

Resource Relation:: Patent File Date: 12/18/2019

Country of Publication:: United States

Language:: English

References (20)

Bias in assessments of marine microbial biodiversity in fosmid libraries as evaluated by pyrosequencing Temperton, Ben; Field, Dawn; Oliver, Anna The ISME Journal, Vol. 3, Issue 7 https://doi.org/10.1038/ismej.2009.32	journal	April 2009
Selection of biocatalysts for chemical synthesis van Sint Fiet, S.; van Beilen, J. B.; Witholt, B. Proceedings of the National Academy of Sciences, Vol. 103, Issue 6 https://doi.org/10.1073/pnas.0504733102	journal	January 2006
Bacterial Mutants for Enhanced Succinate Production Baart, Gino J. E.; Beauprez, Joeri J. R.; Foulquie Moreno, Maria R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110177570 US Patent Application 12/737303; 20110177570	patent-application	July 2011
Self-Replicating Vector Lacking an Antibiotic-Resistance Gene Sodoyer, Regis; Speck, Denis; Peubez, Isabelle https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110207173 US Patent Document 13/054427; 20110207173	patent-application	August 2011
Method For Identifying A Biosynthetic Pathway Gene Product Keasling, Jay D.; Newman, Jack D.; Pitera, Douglas J. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070141574 US Patent Application 10/573796; 20070141574 A1	patent-application	June 2007
Reversible, Parallel and Multitask Cloning Method and Kit Szpirer, Cedric; Milinkovitch, Michel C.; Gabant, Philippe https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130115658 US Patent Application 13/660907; 20130115658	patent-application	May 2013
Method for Producing High Amount of Glycolic Acid by Fermentation Dischert, Wanda; Soucaille, Philippe https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120315682 US Patent Application 13/258366; 20120315682	patent-application	December 2012
Tracking, tuning, and terminating microbial physiology using synthetic riboregulators Callura, J. M.; Dwyer, D. J.; Isaacs, F. J. Proceedings of the National Academy of Sciences, Vol. 107, Issue 36 https://doi.org/10.1073/pnas.1009747107	journal	August 2010
Plasmid addiction systems: perspectives and applications in biotechnology Kroll, Jens; Klinter, Stefan; Schneider, Cornelia Microbial Biotechnology, Vol. 3, Issue 6 https://doi.org/10.1111/j.1751-7915.2010.00170.x	journal	April 2010
Bio-Field Programmable Gate Array and Bio-Programmable Logic Array: Reconfigurable Chassis Construction Babb, Jonathan William; Weiss, Ron; Knight, Thomas https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110257041 US Patent Application 12/946604; 20110257041	patent-application	October 2011
Linear DNA Molecule Delivery Using Pegylated Quantum Dots for Stable Trasformation in Plants Samboju, Narasimha C.; Yau, Kerrm Y.; Burroughs, Frank https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120023619 US Patent Application 13/178199; 20120023619	patent-application	January 2012
Growth differentiation factor promoter and uses therefor Liang, Li-fang https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6555672 US Patent Document 6,555,672	patent	April 2003
Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection Carr, Peter A.; Wang, Harris H.; Sterling, Bram Nucleic Acids Research, Vol. 40, Issue 17 https://doi.org/10.1093/nar/gks455	journal	May 2012
Engineered Microorganisms Capable of Producing Target Compounds Under Anaerobic Conditions Buelter, Thomas; Meinhold, Peter; Feldman, Reid M. Renny https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120190089 US Patent Application 13/303884; 20120190089	patent-application	July 2012
Method of Identifying Compounds Useful to Treat Neuronal Degenerative Diseases Engelhardt, John F.; Zhou, Weihong; Harraz, Maged M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090239243 US Patent Application 11/890775; 20090239243	patent-application	September 2009
Sensors For The Detection Of Intracellular Metabolites Eggeling, Lothar; Bott, Michael; Binder, Stephan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130310458 US Patent Application 13/695769; 20130310458 A1	patent-application	November 2013
Evolution-guided optimization of biosynthetic pathways Raman, Srivatsan; Rogers, Jameson K.; Taylor, Noah D. Proceedings of the National Academy of Sciences, Vol. 111, Issue 50, p. 17803-17808 https://doi.org/10.1073/pnas.1409523111	journal	December 2014
Regulated Transcription of Targeted Genes and Other Biological Events Crabtree, Gerald R.; Schreiber, Stuart L.; Spencer, David M. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110003385 US Patent Application 12/684784; 20110003385	patent-application	January 2011
mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria Engelberg-Kulka, H. Journal of Cell Science, Vol. 118, Issue 19 https://doi.org/10.1242/jcs.02619	journal	September 2005
Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites Church, George M.; Raman, Srivatsan; Taylor, Noah D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/10550384 US Patent Document 10,550,384	patent	February 2020

Similar Records

Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites

Patent · Tue Feb 04 00:00:00 EST 2020 · OSTI ID:1987218

Church, George M.; Raman, Srivatsan; Taylor, Noah D.; +1 more

Genetically encoded sensors enable real-time observation of metabolite production

Journal Article · Mon Feb 08 00:00:00 EST 2016 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1987218

Rogers, Jameson K.; Church, George M.

Engineering microbes for efficient production of chemicals

Patent · Tue Apr 28 00:00:00 EDT 2015 · OSTI ID:1987218

Gong, Wei; Dole, Sudhanshu; Grabar, Tammy; +3 more

Title: Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites

Citation Formats

References (20)

Similar Records

Related Subjects