Antigenic combinations against Francisella bacteria and related nanolipoprotein particles, compositions, methods and systems

Fischer, Nicholas; Rasley, Amy; Wu, Terry; Lovchik, Julie A.

Title: Antigenic combinations against Francisella bacteria and related nanolipoprotein particles, compositions, methods and systems

Patent · Tue Nov 08 00:00:00 EST 2022

OSTI ID:1986801

Fischer, Nicholas; Rasley, Amy; Wu, Terry; Lovchik, Julie A.

Provided herein are antigenic combinations and related compositions, methods and systems for immunizing a host from an infection caused by Francisella bacterium. The antigenic combination comprises an antigenic polysaccharide component from a Francisella bacterium capable of triggering a humoral immune response in an individual, a protein antigen component from the Francisella bacterium capable of triggering a cellular immune response in the individual, and an adjuvant, the antigenic Francisella polysaccharide component, the Francisella protein antigen component and the adjuvant are in a suitable amount to immunize an individual against the Francisella bacterium.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); Univ. of New Mexico, Albuquerque, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA); Regents of the University of New Mexico (Albuquerque, NM)

Patent Number(s):: 11,491,215

Application Number:: 16/543,463

OSTI ID:: 1986801

Resource Relation:: Patent File Date: 08/16/2019

Country of Publication:: United States

Language:: English

References (47)

Purified Lipopolysaccharide from Francisella tularensis Live Vaccine Strain (LVS) Induces Protective Immunity against LVS Infection That Requires B Cells and Gamma Interferon Dreisbach, V. C.; Cowley, S.; Elkins, K. L. Infection and Immunity, Vol. 68, Issue 4 https://doi.org/10.1128/IAI.68.4.1988-1996.2000	journal	April 2000
Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14 Watanabe, Sachiko; Kumazawa, Yoshio; Inoue, Joe PLoS ONE, Vol. 8, Issue 4 https://doi.org/10.1371/journal.pone.0060078	journal	April 2013
Intranasal administration of a two-dose adjuvanted multi-antigen TMV-subunit conjugate vaccine fully protects mice against Francisella tularensis LVS challenge McCormick, Alison A.; Shakeel, Aisha; Yi, Chris PLOS ONE, Vol. 13, Issue 4 https://doi.org/10.1371/journal.pone.0194614	journal	April 2018
The atypical lipopolysaccharide ofFrancisella Okan, Nihal A.; Kasper, Dennis L. Carbohydrate Research, Vol. 378 https://doi.org/10.1016/j.carres.2013.06.015	journal	August 2013
Elevation of Francisella philomiragia subsp. noatunensis Mikalsen et al. (2007) to Francisella noatunensis comb. nov. [syn. Francisella piscicida Ottem et al. (2008) syn. nov.] and characterization of Francisella noatunensis subsp . orientalis subsp. nov., two important fish pathogens Ottem, K. F.; Nylund, A.; Karlsbakk, E. Journal of Applied Microbiology, Vol. 106, Issue 4 https://doi.org/10.1111/j.1365-2672.2008.04092.x	journal	April 2009
Vaccines against tularemia Horwitz, Marcus A.; Jia, Qingmei; Clemens, Bai-Yu Lee https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8481024 US Patent Document 8,481,024	patent	July 2013
The type and yield of lipopolysaccharide from symbiotically deficient Rhizobium lipopolysaccharide mutants vary depending on the extraction method Ridley, B. L.; Jeyaretnam, B. S.; Carlson, R. W. Glycobiology, Vol. 10, Issue 10 https://doi.org/10.1093/glycob/10.10.1013	journal	October 2000
Structural Analysis of a Protective Epitope of the Francisella tularensis O-Polysaccharide Rynkiewicz, Michael J.; Lu, Zhaohua; Hui, Julia H. Biochemistry, Vol. 51, Issue 28 https://doi.org/10.1021/bi201711m	journal	July 2012
Characterization of Lipid A Acylation Patterns in Francisella tularensis , Francisella novicida , and Francisella philomiragia Using Multiple-Stage Mass Spectrometry and Matrix-Assisted Laser Desorption/Ionization on an Intermediate Vacuum Source Linear Ion Trap Schilling, Birgit; McLendon, Molly K.; Phillips, Nancy J. Analytical Chemistry, Vol. 79, Issue 3 https://doi.org/10.1021/ac061654e	journal	February 2007
Antibodies to Both Terminal and Internal B-Cell Epitopes of Francisella tularensisO-Polysaccharide Produced by Patients with Tularemia Lu, Zhaohua; Perkins, Hillary M.; Sharon, Jacqueline Clinical and Vaccine Immunology, Vol. 21, Issue 2 https://doi.org/10.1128/CVI.00626-13	journal	December 2013
Francisella guangzhouensis sp. nov., isolated from air-conditioning systems Qu, P. -H.; Chen, S. -Y.; Scholz, H. C. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 63, Issue Pt 10 https://doi.org/10.1099/ijs.0.049916-0	journal	April 2013
New protein fold revealed by a 1.65 Å resolution crystal structure of Francisella tularensis pathogenicity island protein IglC Sun, Ping; Austin, Brian P.; Schubot, Florian D. Protein Science, Vol. 16, Issue 11 https://doi.org/10.1110/ps.073177307	journal	November 2007
Protective B-cell epitopes of Francisella tularensis O-polysaccharide in a mouse model of respiratory tularaemia: Protective epitopes of Francisella tularensis O-antigen Lu, Zhaohua; Madico, Guillermo; Roche, Marly I. Immunology, Vol. 136, Issue 3 https://doi.org/10.1111/j.1365-2567.2012.03589.x	journal	June 2012
High Throughput T Epitope Mapping and Vaccine Development Li Pira, Giuseppina; Ivaldi, Federico; Moretti, Paolo Journal of Biomedicine and Biotechnology, Vol. 2010 https://doi.org/10.1155/2010/325720	journal	January 2010
The Immunologically Distinct O Antigens from Francisella tularensis Subspecies tularensis and Francisella novicida Are both Virulence Determinants and Protective Antigens Thomas, R. M.; Titball, R. W.; Oyston, P. C. F. Infection and Immunity, Vol. 75, Issue 1 https://doi.org/10.1128/IAI.01241-06	journal	October 2006
Nanolipoprotein particles and related compositions, methods and systems Hoeprich, Jr., Paul D.; Fischer, Nicholas O.; Mason, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8883729 US Patent Document 8,883,729	patent	November 2014
Identification of common molecular subsequences Smith, T. F.; Waterman, M. S. Journal of Molecular Biology, Vol. 147, Issue 1, p. 195-197 https://doi.org/10.1016/0022-2836(81)90087-5	journal	March 1981
Multivalent Liposomal Vaccine Compositions Comprising Polysaccharide Antigens and a Protein Adjuvant Bacon, Andrew David; Gregoriadis, Gregory; Laing, Peter https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090068254 US Patent Application 12/088656; 20090068254	patent-application	March 2009
Tularemia Foley, Janet E.; Nieto, Nathan C. Veterinary Microbiology, Vol. 140, Issue 3-4 https://doi.org/10.1016/j.vetmic.2009.07.017	journal	January 2010
Description of Francisella hispaniensis sp. nov., isolated from human blood, reclassification of Francisella novicida (Larson et al. 1955) Olsufiev et al. 1959 as Francisella tularensis subsp. novicida comb. nov. and emended description of the genus Francisella Huber, B.; Escudero, R.; Busse, H. -J. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, Vol. 60, Issue 8 https://doi.org/10.1099/ijs.0.015941-0	journal	September 2009
Searching protein sequence libraries: Comparison of the sensitivity and selectivity of the Smith-Waterman and FASTA algorithms Pearson, William R. Genomics, Vol. 11, Issue 3 https://doi.org/10.1016/0888-7543(91)90071-L	journal	November 1991
Characterization of Monoclonal Antibodies to Terminal and Internal O-Antigen Epitopes ofFrancisella tularensisLipopolysaccharide Roche, Marly I.; Lu, Zhaohua; Hui, Julia H. Hybridoma, Vol. 30, Issue 1 https://doi.org/10.1089/hyb.2010.0083	journal	February 2011
A simple practice guide for dose conversion between animals and human Nair, AnroopB; Jacob, Shery Journal of Basic and Clinical Pharmacy, Vol. 7, Issue 2 https://doi.org/10.4103/0976-0105.177703	journal	January 2016
Role of lipopolysaccharide and a major outer membrane protein from Francisella tularensis in the induction of immunity against tularemia Fulop, Mark; Manchee, Richard; Titball, Richard Vaccine, Vol. 13, Issue 13 https://doi.org/10.1016/0264-410X(95)00062-6	journal	January 1995
A high-throughput shotgun mutagenesis approach to mapping B-cell antibody epitopes Davidson, Edgar; Doranz, Benjamin J. Immunology, Vol. 143, Issue 1 https://doi.org/10.1111/imm.12323	journal	July 2014
Lack of In Vitro and In Vivo Recognition of Francisella tularensis Subspecies Lipopolysaccharide by Toll-Like Receptors Hajjar, Adeline M.; Harvey, Megan D.; Shaffer, Scott A. Infection and Immunity, Vol. 74, Issue 12 https://doi.org/10.1128/IAI.00934-06	journal	December 2006
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs Altschul, Stephen F.; Madden, Thomas L.; Schäffer, Alejandro A. Nucleic Acids Research, Vol. 25, Issue 17, p. 3389-3402 https://doi.org/10.1093/nar/25.17.3389	journal	September 1997
Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface Stead, Christopher M.; Zhao, Jinshi; Raetz, Christian R. H. Molecular Microbiology, Vol. 78, Issue 4 https://doi.org/10.1111/j.1365-2958.2010.07304.x	journal	November 2010
Immunostimulatory nanoparticles and related compositions, methods and systems Hoeprich, Jr., Paul D.; Fischer, Nicholas O.; Blanchette, Craig D. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8889623 US Patent Document 8,889,623	patent	November 2014
Francisella asiatica sp. nov. isolated from farmed tilapia (Oreochromis sp.) and elevation of Francisella philomiragia subsp. noatunensis to species rank as Francisella noatunensis comb. nov., sp. nov. Mikalsen, J.; Colquhoun, D. J. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY https://doi.org/10.1099/ijs.0.002139-0	journal	September 2009
Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis Prior, J. L. Journal of Medical Microbiology, Vol. 52, Issue 10 https://doi.org/10.1099/jmm.0.05184-0	journal	October 2003
A two-component Kdo hydrolase in the inner membrane of Francisella novicida Zhao, Jinshi; Raetz, Christian R. H. Molecular Microbiology, Vol. 78, Issue 4 https://doi.org/10.1111/j.1365-2958.2010.07305.x	journal	November 2010
Mice vaccinated with the O-antigen of Francisella tularensis LVS lipopolysaccharide conjugated to bovine serum albumin develop varying degrees of protective immunity against systemic or aerosol challenge with virulent type A and type B strains of the pathogen Conlan, J. Wayne; Shen, Hua; Webb, Ann Vaccine, Vol. 20, Issue 29-30 https://doi.org/10.1016/S0264-410X(02)00345-6	journal	October 2002
Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis Fulop, Mark; Mastroeni, Pietro; Green, Michael Vaccine, Vol. 19, Issue 31 https://doi.org/10.1016/S0264-410X(01)00189-X	journal	August 2001
Metabolic labeling to characterize the overall composition ofFrancisellalipid A and LPS grown in broth and in human phagocytes Barker, Jason H.; Kaufman, Justin W.; Zhang, De-Sheng Innate Immunity, Vol. 20, Issue 1 https://doi.org/10.1177/1753425913485308	journal	May 2013
Protection induced by a Francisella tularensis subunit vaccine delivered by glucan particles Whelan, Adam O.; Flick-Smith, Helen C.; Homan, Jane PLOS ONE, Vol. 13, Issue 10 https://doi.org/10.1371/journal.pone.0200213	journal	October 2018
Improved tools for biological sequence comparison. Pearson, W. R.; Lipman, D. J. Proceedings of the National Academy of Sciences, Vol. 85, Issue 8, p. 2444-2448 https://doi.org/10.1073/pnas.85.8.2444	journal	April 1988
A Mucosal Subunit Vaccine Protects against Lethal Respiratory Infection with Francisella tularensis LVS Ashtekar, Amit R.; Katz, Jannet; Xu, Qingan PLoS ONE, Vol. 7, Issue 11 https://doi.org/10.1371/journal.pone.0050460	journal	November 2012
3-Deoxy-d-manno-octulosonic Acid (Kdo) Hydrolase Identified in Francisella tularensis, Helicobacter pylori, and Legionella pneumophila Chalabaev, Sabina; Kim, Tae-Hyun; Ross, Robin Journal of Biological Chemistry, Vol. 285, Issue 45 https://doi.org/10.1074/jbc.M110.166314	journal	November 2010
Hidden Markov model speed heuristic and iterative HMM search procedure Johnson, L. Steven; Eddy, Sean R.; Portugaly, Elon BMC Bioinformatics, Vol. 11, Issue 1 https://doi.org/10.1186/1471-2105-11-431	journal	August 2010
Evidence Suggesting That Francisella tularensis O-Antigen Capsule Contains a Lipid A-Like Molecule That Is Structurally Distinct from the More Abundant Free Lipid A Barker, Jason H.; Kaufman, Justin W.; Apicella, Michael A. PLOS ONE, Vol. 11, Issue 6 https://doi.org/10.1371/journal.pone.0157842	journal	June 2016
Mice intradermally-inoculated with the intact lipopolysaccharide, but not the lipid A or O-chain, from Francisella tularensis LVS rapidly acquire varying degrees of enhanced resistance against systemic or aerogenic challenge with virulent strains of the pathogen Conlan, J. Wayne; Vinogradov, Evguenii; Monteiro, Mario A. Microbial Pathogenesis, Vol. 34, Issue 1 https://doi.org/10.1016/S0882-4010(02)00194-8	journal	January 2003
Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein Koren, E.; De Groot, A. S.; Jawa, V. Clinical Immunology, Vol. 124, Issue 1 https://doi.org/10.1016/j.clim.2007.03.544	journal	July 2007
Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates Post, Deborah M. B.; Slütter, Bram; Schilling, Birgit mBio, Vol. 8, Issue 5 https://doi.org/10.1128/mBio.01592-17	journal	October 2017
Targeted Inactivation ofFrancisella tularensisGenes by Group II Introns Rodriguez, Stephen A.; Yu, Jieh-Juen; Davis, Greg Applied and Environmental Microbiology, Vol. 74, Issue 9 https://doi.org/10.1128/AEM.02905-07	journal	May 2008
Functional and Structural Characterization ofFrancisella tularensis O-Antigen Antibodies at the Low End of Antigen Reactivity Lu, Zhaohua; Rynkiewicz, Michael J.; Yang, Chiou-Ying Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Vol. 33, Issue 4 https://doi.org/10.1089/mab.2014.0022	journal	August 2014
Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge Cole, L. E.; Yang, Y.; Elkins, K. L. Proceedings of the National Academy of Sciences, Vol. 106, Issue 11 https://doi.org/10.1073/pnas.0813411106	journal	February 2009

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