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Title: Genetically-modified bacteria for conversion of organic compounds to butanol and methods of use

Patent ·
OSTI ID:1986678
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This disclosure provides a genetically-modified bacterium from the genus Megasphaera that comprises an exogenous nucleic acid encoding a bifunctional aldehyde/alcohol dehydrogenase that produces butanol as the final product. The disclosure further provides methods for producing butanol using such genetically-modified bacterium.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-00OR22725
Assignee:
UT-Battelle LLC (Oak Ridge, TN)
Patent Number(s):
11,466,296
Application Number:
16/934,359
OSTI ID:
1986678
Resource Relation:
Patent File Date: 07/21/2020
Country of Publication:
United States
Language:
English

References (9)

Production of high-concentration n-caproic acid from lactate through fermentation using a newly isolated Ruminococcaceae bacterium CPB6 journal April 2017
Enterohepatic Helicobacter in Ulcerative Colitis: Potential Pathogenic Entities? journal February 2011
Poly-Lactic Acid: Production, Applications, Nanocomposites, and Release Studies journal August 2010
Application of Functional Genomics to Pathway Optimization for Increased Isoprenoid Production journal March 2008
Microbial production of lactic acid: the latest development journal August 2015
Biotechnological routes based on lactic acid production from biomass journal November 2011
Production of itaconic acid and related molecules from aromatic compounds patent-application October 2019
Electrolytic extraction drives volatile fatty acid chain elongation through lactic acid and replaces chemical pH control in thin stillage fermentation journal December 2015
Production of medium-chain carboxylic acids by Megasphaera sp. MH with supplemental electron acceptors journal June 2016

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