Tungsten disulfide nanotubes enhance flow-induced crystallization and radio-opacity of polylactide without adversely affecting in vitro toxicity

Ramachandran, Karthik; Shao, Zixuan; Di Luccio, Tiziana; Shen, Bo; Bello, Edgar Ruiz; Tammaro, Loredana; Villani, Fulvia; Loffredo, Fausta; Borriello, Carmela; Di Benedetto, Francesca; Magee, Eimear; McNally, Tony; Kornfield, Julia A.

doi:10.1016/j.actbio.2021.11.005

Title: Tungsten disulfide nanotubes enhance flow-induced crystallization and radio-opacity of polylactide without adversely affecting in vitro toxicity

Journal Article · Wed Nov 17 00:00:00 EST 2021 · Acta Biomaterialia

DOI:https://doi.org/10.1016/j.actbio.2021.11.005· OSTI ID:1981526

Ramachandran, Karthik ^[1];

^[2];

^[3]; Shen, Bo ^[4];

^[5]; Tammaro, Loredana ^[6];

^[6]; Loffredo, Fausta ^[6];

^[6]; Di Benedetto, Francesca ^[7]; Magee, Eimear ^[8]; McNally, Tony ^[8];

^[4]

California Institute of Technology, Pasadena, CA (United States); Moderna, Cambridge, MA (United States)
California Institute of Technology, Pasadena, CA (United States); Allegro Ophthalmics, LLC, San Juan Capistrano, CA (United States)
California Institute of Technology, Pasadena, CA (United States); ENEA Centro Ricerche Portici (Italy)
California Institute of Technology, Pasadena, CA (United States)
California Institute of Technology, Pasadena, CA (United States); University of Guanajuato (Mexico)
ENEA Centro Ricerche Portici (Italy)
ENEA Centro Ricerche Brindisi (Italy)
University of Warwick (United Kingdom)

Treatment of vascular disease, from peripheral ischemia to coronary heart disease (CHD), is poised for transformation with the introduction of transient implants designed to “scaffold” regeneration of blood vessels and ultimately leave nothing behind. Improved materials could expand the use of these devices. Here, we examine one of the leading polymers for bioresorbable scaffolds (BRS), polylactide (PLA), as the matrix of nanocomposites with tungsten disulfide (WS₂) nanotubes (WSNT), which may provide mechanical reinforcement and enhance radio-opacity. We evaluate in vitro cytotoxicity using vascular cells, flow-induced crystallization and radio-opacity of PLA-WSNT nanocomposites at low WSNT concentration. A small amount of WSNT (0.1 wt%) can effectively promote oriented crystallization of PLA without compromising molecular weight. And radio-opacity improves significantly: as little as 0.5 to 1 wt% WSNT doubles the radio-opacity of PLA-WSNT relative to PLA at 17 keV. The results suggest that a single component, WSNT, has the potential to increase the strength of BRS to enable thinner devices and increase radio-opacity to improve intraoperative visualization. Here, the in vitro toxicity results indicate that PLA-WSNT nanocomposites are worthy of investigation in vivo. Although substantial further preclinical studies are needed, PLA-WSNT nanocomposites may provide a complement of material properties that may improve BRS and expand the range of lesions that can be treated using transient implants.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-06CH11357; T32GM112592

OSTI ID:: 1981526

Journal Information:: Acta Biomaterialia, Vol. 138, Issue C; ISSN 1742-7061

Publisher:: Acta Materialia, Inc.Copyright Statement

Country of Publication:: United States

Language:: English

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36 MATERIALS SCIENCE
Engineering
Materials Science
Polylactide (PLA)
Tungsten disulfide (WS2) nanotubes
Flow-induced crystallization
Biocompatible nanocomposites
Coronary Heart Disease
Bioresorbable Vascular Scaffolds (BVS)

Title: Tungsten disulfide nanotubes enhance flow-induced crystallization and radio-opacity of polylactide without adversely affecting in vitro toxicity

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