Interrogating the role of the milk microbiome in mastitis in the multi-omics era

Couvillion, Sneha P.; Mostoller, Katie E.; Williams, Janet E.; Pace, Ryan M.; Stohel, Izabel L.; Peterson, Haley K.; Nicora, Carrie D.; Nakayasu, Ernesto S.; Webb-Robertson, Bobbie-Jo M.; McGuire, Mark A.; McGuire, Michelle K.; Metz, Thomas O.

doi:10.3389/fmicb.2023.1105675

Title: Interrogating the role of the milk microbiome in mastitis in the multi-omics era

Journal Article · Thu Feb 02 00:00:00 EST 2023 · Frontiers in Microbiology

DOI:https://doi.org/10.3389/fmicb.2023.1105675· OSTI ID:1964096

Couvillion, Sneha P. ^[1]; Mostoller, Katie E. ^[1]; Williams, Janet E. ^[2]; Pace, Ryan M. ^[2]; Stohel, Izabel L. ^[1]; Peterson, Haley K. ^[2];

^[1];

^[1]; Webb-Robertson, Bobbie-Jo M. ^[1]; McGuire, Mark A. ^[2]; McGuire, Michelle K. ^[2];

^[1]

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
University of Idaho, Moscow, ID (United States)

There is growing interest in a functional understanding of milk-associated microbiota as there is ample evidence that host-associated microbial communities play an active role in host health and phenotype. Mastitis, characterized by painful inflammation of the mammary gland, is prevalent among lactating humans and agricultural animals and is associated with significant clinical and economic consequences. The etiology of mastitis is complex and polymicrobial and correlative studies have indicated alterations in milk microbial community composition. Recent evidence is beginning to suggest that a causal relationship may exist between the milk microbiota and host phenotype in mastitis. Multi-omic approaches can be leveraged to gain a mechanistic, molecular level understanding of how the milk microbiome might modulate host physiology, thereby informing strategies to prevent and ameliorate mastitis. In this paper, we review existing studies that have utilized omics approaches to investigate the role of the milk microbiome in mastitis. We also summarize the strengths and challenges associated with the different omics techniques including metagenomics, metatranscriptomics, metaproteomics, metabolomics and lipidomics and provide perspective on the integration of multiple omics technologies for a better functional understanding of the milk microbiome.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institutes of Health (NIH); US Department of Agriculture (USDA)

Grant/Contract Number:: AC05-76RL01830; R01 HD092297

OSTI ID:: 1964096

Report Number(s):: PNNL-SA-180041

Journal Information:: Frontiers in Microbiology, Vol. 14; ISSN 1664-302X

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
milk
multi-omics
mastitis
metagenomics
metatranscriptomics
metaproteomics
metabolomics
lipidomics

Title: Interrogating the role of the milk microbiome in mastitis in the multi-omics era

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