Ceftazidime-Avibactam: A Review in the Treatment of Serious Gram-Negative Bacterial Infections
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journal
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April 2018 |
The structure of Toho1 β-lactamase in complex with penicillin reveals the role of Tyr105 in substrate recognition
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November 2016 |
β-Lactamase of Mycobacterium tuberculosis Shows Dynamics in the Active Site That Increase upon Inhibitor Binding
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February 2020 |
Neutron and X-ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 β-Lactamase for the Acylation Reaction
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December 2012 |
Comparative Analysis of Threshold and Tessellation Methods for Determining Protein Contacts
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January 2011 |
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
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July 2013 |
β-Lactamases and β-Lactamase Inhibitors in the 21st Century
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August 2019 |
Scalable molecular dynamics with NAMD
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January 2005 |
The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.
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March 1996 |
Theoretical insights on the inhibition mechanism of a class A Serine Hydrolase by avibactam
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April 2018 |
The ABCD’s of β-lactamase nomenclature
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January 2013 |
Improvement of crystal quality by surface mutations of β-lactamase Toho-1
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March 2009 |
NMR methods for the determination of protein–ligand dissociation constants
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November 2007 |
Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes
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March 1977 |
Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.
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December 1993 |
Molecular Mechanism of Avibactam-Mediated β-Lactamase Inhibition
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February 2015 |
Three Decades of -Lactamase Inhibitors
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January 2010 |
Probing the role of the conserved residue Glu166 in a class A β-lactamase using neutron and X-ray protein crystallography
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January 2020 |
NMR Dynamics of PSE-4 β-Lactamase: An Interplay of ps-ns Order and μs-ms Motions in the Active Site
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June 2009 |
Protein dynamics from NMR
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July 1998 |
Backbone dynamics of proteins as studied by nitrogen-15 inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease
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November 1989 |
Slow Dynamics in Folded and Unfolded States of an SH3 Domain
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November 2001 |
NmrLineGuru: Standalone and User-Friendly GUIs for Fast 1D NMR Lineshape Simulation and Analysis of Multi-State Equilibrium Binding Models
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November 2019 |
Spin Echoes and Chemical Exchange
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March 1965 |
Backbone Dynamics of TEM-1 Determined by NMR: Evidence for a Highly Ordered Protein †
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September 2006 |
UCSF Chimera?A visualization system for exploratory research and analysis
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January 2004 |
I-PINE web server: an integrative probabilistic NMR assignment system for proteins
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May 2019 |
Conformational dynamics and enzyme evolution
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journal
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July 2018 |
Avibactam is a covalent, reversible, non- -lactam -lactamase inhibitor
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July 2012 |
Error estimation and global fitting in transverse-relaxation dispersion experiments to determine chemical-exchange parameters
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May 2005 |
Probabilistic Interaction Network of Evidence Algorithm and its Application to Complete Labeling of Peak Lists from Protein NMR Spectroscopy
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March 2009 |
Using chemical shift perturbation to characterise ligand binding
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August 2013 |
Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks
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June 2013 |
PINE-SPARKY.2 for automated NMR-based protein structure research
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December 2017 |
Exploring the Mechanism of β-Lactam Ring Protonation in the Class A β-lactamase Acylation Mechanism Using Neutron and X-ray Crystallography
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December 2015 |
NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy
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December 2014 |
Role of the Ω-Loop in the Activity, Substrate Specificity, and Structure of Class A β-Lactamase † , ‡
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March 1998 |
Deviations from the simple two-parameter model-free approach to the interpretation of nitrogen-15 nuclear magnetic relaxation of proteins
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June 1990 |
TEM-1 Backbone Dynamics—Insights from Combined Molecular Dynamics and Nuclear Magnetic Resonance
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February 2010 |
Current Challenges in Antimicrobial Chemotherapy
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April 2010 |
Bench-to-bedside review: The role of β-lactamases in antibiotic-resistant Gram-negative infections
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January 2010 |
Molecular Insights on the Release of Avibactam from the Acyl-Enzyme Complex
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May 2019 |
What Contributions to Protein Side-chain Dynamics are Probed by NMR Experiments? A Molecular Dynamics Simulation Analysis
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May 2005 |
Information flow and protein dynamics: the interplay between nuclear magnetic resonance spectroscopy and molecular dynamics simulations
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May 2015 |
CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis
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September 2016 |
Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamase isolated from Escherichia coli
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October 1995 |
Beta-lactam antibiotics: from antibiosis to resistance and bacteriology: BETA-LACTAM RESISTANCE
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January 2010 |
Excess positional mutual information predicts both local and allosteric mutations affecting beta lactamase drug resistance
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July 2016 |
An Effective Method for the Discrimination of Motional Anisotropy and Chemical Exchange
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March 2002 |
Backbone Dynamics ofEscherichia coliRibonuclease HI: Correlations with Structure and Function in an Active Enzyme
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February 1995 |
Variations within Class-A β-Lactamase Physiochemical Properties Reflect Evolutionary and Environmental Patterns, but not Antibiotic Specificity
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July 2013 |
Appropriateness of DSS and TSP as internal references for 1H NMR studies of molten globule proteins in aqueous media
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November 1994 |
Rotational diffusion anisotropy of human ubiquitin from 15N NMR relaxation
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December 1995 |
Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme
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October 2014 |
An introduction to NMR-based approaches for measuring protein dynamics
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journal
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August 2011 |
The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation
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June 2017 |
Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam
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March 2020 |
Acyl-intermediate Structures of the Extended-spectrum Class A β-Lactamase, Toho-1, in Complex with Cefotaxime, Cephalothin, and Benzylpenicillin
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journal
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September 2002 |
Ceftazidime–avibactam: an evidence-based review of its pharmacology and potential use in the treatment of Gram-negative bacterial infections
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January 2014 |
Substrate Binding Induces Conformational Changes in a Class A β-lactamase That Prime It for Catalysis
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journal
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January 2018 |
Molecular Dynamics of Class A β-lactamases—Effects of Substrate Binding
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October 2012 |
NMR Order Parameter Determination from Long Molecular Dynamics Trajectories for Objective Comparison with Experiment
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May 2014 |
TROSY and CRINEPT: NMR with large molecular and supramolecular structures in solution
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October 2000 |
Following the Reactions of Mechanism-Based Inhibitors with β-Lactamase by Raman Crystallography
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October 2003 |
Nuclear Spin Relaxation in Ellipsoids Undergoing Rotational Brownian Motion
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August 1962 |
Modelling proteins’ hidden conformations to predict antibiotic resistance
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October 2016 |
A suite of Mathematica notebooks for the analysis of protein main chain 15N NMR relaxation data
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October 2006 |
Backbone dynamics of calmodulin studied by nitrogen-15 relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible
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July 1992 |
Structural Insight into Potent Broad-Spectrum Inhibition with Reversible Recyclization Mechanism: Avibactam in Complex with CTX-M-15 and Pseudomonas aeruginosa AmpC β-Lactamases
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February 2013 |
Linear analysis of carbon-13 chemical shift differences and its application to the detection and correction of errors in referencing and spin system identifications
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journal
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May 2005 |
ChemInform Abstract: MODEL-FREE APPROACH TO THE INTERPRETATION OF NUCLEAR MAGNETIC RESONANCE RELAXATION IN MACROMOLECULES. 1. THEORY AND RANGE OF VALIDITY
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November 1982 |
TROSY in NMR studies of the structure and function of large biological macromolecules
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October 2003 |
Prediction of Hydrodynamic and Other Solution Properties of Rigid Proteins from Atomic- and Residue-Level Models
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August 2011 |
VMD: Visual molecular dynamics
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February 1996 |
A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis
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February 2015 |
Neutron Diffraction Studies of a Class A β-Lactamase Toho-1 E166A/R274N/R276N Triple Mutant
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March 2010 |
Combined chemical shift changes and amino acid specific chemical shift mapping of protein–protein interactions
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October 2007 |