Peptides having reduced toxicity that stimulate cholesterol efflux

Bielicki, John K.; Johansson, Jan; Danho, Waleed

Title: Peptides having reduced toxicity that stimulate cholesterol efflux

Patent · Tue Sep 06 00:00:00 EDT 2022

OSTI ID:1925053

Bielicki, John K.; Johansson, Jan; Danho, Waleed

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer's Disease or frontotemporal dementia.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE; National Institutes of Health (NIH)

DOE Contract Number:: AC02-05CH11231; HL085791

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 11,434,267

Application Number:: 17/016,541

OSTI ID:: 1925053

Resource Relation:: Patent File Date: 09/10/2020

Country of Publication:: United States

Language:: English

References (23)

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