Selective high-affinity polydentate ligands and methods of making such
Patent
·
OSTI ID:1892739
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States); Univ. of California, Oakland, CA (United States)
- Sponsoring Organization:
- USDOE; Nation Cancer Institute (NCI)
- DOE Contract Number:
- AC52-07NA27344; CA047829
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA); The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 11,285,165
- Application Number:
- 16/843,783
- OSTI ID:
- 1892739
- Resource Relation:
- Patent File Date: 04/08/2020
- Country of Publication:
- United States
- Language:
- English
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