COMPASS: A complex of proteins associated with a trithorax-related SET domain protein
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October 2001 |
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4
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December 2001 |
WDR5, a complexed protein
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July 2009 |
WD40 repeat domain proteins: a novel target class?
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October 2017 |
Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide
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October 2008 |
A Conserved Arginine-containing Motif Crucial for the Assembly and Enzymatic Activity of the Mixed Lineage Leukemia Protein-1 Core Complex
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October 2008 |
Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone Methyltransferases
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June 2012 |
In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer
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June 2016 |
WDR5 Expression Is Prognostic of Breast Cancer Outcome
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September 2015 |
Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation
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February 2015 |
PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407
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March 2017 |
TWIST1-WDR5- Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis
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May 2017 |
Up‐regulated WDR5 promotes gastric cancer formation by induced cyclin D1 expression
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December 2017 |
Overexpression of WD repeat domain 5 associates with aggressive clinicopathological features and unfavorable prognosis in head neck squamous cell carcinoma
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April 2018 |
WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma
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October 2015 |
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance
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November 2019 |
Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC
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May 2015 |
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
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December 2012 |
Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction
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February 2013 |
High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction
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December 2012 |
Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
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January 2014 |
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
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July 2015 |
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
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September 2015 |
Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)
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March 2016 |
High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity
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November 2016 |
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction
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June 2017 |
Discovery of Potent 2-Aryl-6,7-dihydro-5 H -pyrrolo[1,2- a ]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design
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June 2018 |
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
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March 2019 |
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction
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November 2019 |
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core
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December 2019 |
Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design
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March 2020 |
Induced protein degradation: an emerging drug discovery paradigm
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November 2016 |
Targeted protein degradation: expanding the toolbox
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October 2019 |
Advancing targeted protein degradation for cancer therapy
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June 2021 |
Catalytic in vivo protein knockdown by small-molecule PROTACs
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June 2015 |
HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins
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June 2015 |
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer
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January 2019 |
3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation
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June 2018 |
Structural basis of PROTAC cooperative recognition for selective protein degradation
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March 2017 |
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
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June 2016 |
Moonlighting with WDR5: A Cellular Multitasker
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January 2018 |
Plasticity in binding confers selectivity in ligand-induced protein degradation
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June 2018 |
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
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June 2019 |
Structure‐Based Design of a Macrocyclic PROTAC
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December 2019 |
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL
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July 2020 |
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
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November 2020 |
Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders
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January 2020 |
Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus
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July 2005 |
NUP98–NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis
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June 2007 |
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
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January 2015 |
Genome engineering using the CRISPR-Cas9 system
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October 2013 |
Improved vectors and genome-wide libraries for CRISPR screening
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July 2014 |
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
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December 2013 |
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM
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March 2011 |
Scaling and assessment of data quality
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December 2005 |
Phaser crystallographic software
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July 2007 |
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
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April 1999 |
Structural basis for molecular recognition and presentation of histone H3 By WDR5
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August 2006 |
Coot model-building tools for molecular graphics
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November 2004 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
Integrating macromolecular X-ray diffraction data with the graphical user interface iMosflm
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June 2017 |
PRODRG : a tool for high-throughput crystallography of protein–ligand complexes
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July 2004 |
Single-vector inducible lentiviral RNAi system for oncology target validation
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February 2009 |
An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting
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February 2013 |
Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF
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June 2005 |
Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development
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July 2016 |
An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition
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November 2016 |
Fast and accurate long-read alignment with Burrows–Wheeler transform
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January 2010 |
Model-based Analysis of ChIP-Seq (MACS)
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January 2008 |
A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
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April 2011 |
BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis
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November 2020 |
PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation
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August 2019 |
ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer
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October 2018 |
MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery
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August 2010 |
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
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August 2011 |
Differential expression analysis for sequence count data
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October 2010 |
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
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September 2005 |
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice
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April 2016 |
Genomic impact of transient low-dose decitabine treatment on primary AML cells
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February 2013 |