Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

Degteva, Marina O.; Tolstykh, Evgenia I.; Shishkina, Elena A.; Sharagin, Pavel A.; Zalyapin, Vladimir I.; Volchkova, Alexandra Yu.; Smith, Michael A.; Napier, Bruce A.

doi:10.1371/journal.pone.0257605

Title: Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

Journal Article · Thu Oct 14 00:00:00 EDT 2021 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0257605· OSTI ID:1830507

Degteva, Marina O. ^[1]; Tolstykh, Evgenia I. ^[1]; Shishkina, Elena A. ^[2];

^[1];

^[3]; Volchkova, Alexandra Yu. ^[1]; Smith, Michael A. ^[4];

^[4]

Urals Research Center for Radiation Medicine, Chelyabinsk (Russia)
Urals Research Center for Radiation Medicine, Chelyabinsk (Russia); Chelyabinsk State Univ. (Russia)
South Urals State Univ., Chelyabinsk (Russia)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

The objective of this study is to develop a skeleton model for assessing active marrow dose from bone-seeking beta-emitting radionuclides. This article explains the modeling methodology which accounts for individual variability of the macro- and microstructure of bone tissue. Bone sites with active hematopoiesis are assessed by dividing them into small segments described by simple geometric shapes. Spongiosa, which fills the segments, is modeled as an isotropic three-dimensional grid (framework) of rod-like trabeculae that “run through” the bone marrow. Randomized multiple framework deformations are simulated by changing the positions of the grid nodes and the thickness of the rods. Model grid parameters are selected in accordance with the parameters of spongiosa microstructures taken from the published papers. Stochastic modeling of radiation transport in heterogeneous media simulating the distribution of bone tissue and marrow in each of the segments is performed by Monte Carlo methods. Model output for the human femur at different ages is provided as an example. The uncertainty of dosimetric characteristics associated with individual variability of bone structure was evaluated. An advantage of this methodology for the calculation of doses absorbed in the marrow from bone-seeking radionuclides is that it does not require additional studies of autopsy material. The biokinetic model results will be used in the future to calculate individual doses to members of a cohort exposed to ^89,90Sr from liquid radioactive waste discharged to the Techa River by the Mayak Production Association in 1949–1956. Further study of these unique cohorts provides an opportunity to gain more in-depth knowledge about the effects of chronic radiation on the hematopoietic system. In addition, the proposed model can be used to assess the doses to active marrow under any other scenarios of ⁹⁰Sr and ⁸⁹Sr intake to humans.

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Research Organization:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1830507

Report Number(s):: PNNL-SA-160646

Journal Information:: PLoS ONE, Vol. 16, Issue 10; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Stochastic parametric skeletal dosimetry model for humans: General approach and application to active marrow exposure from bone-seeking beta-particle emitters

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