Validation of the TOPAS Monte Carlo toolkit for HDR brachytherapy simulations

Berumen, Francisco; Ma, Yunzhi; Ramos-Méndez, José; Perl, Joseph; Beaulieu, Luc

doi:10.1016/j.brachy.2020.12.007

Title: Validation of the TOPAS Monte Carlo toolkit for HDR brachytherapy simulations

Journal Article · Fri Apr 23 00:00:00 EDT 2021 · Brachytherapy

DOI:https://doi.org/10.1016/j.brachy.2020.12.007· OSTI ID:1818227

^[1]; Ma, Yunzhi ^[1]; Ramos-Méndez, José ^[2]; Perl, Joseph ^[3];

^[1]

Centre Hospitalier Univ. de Quebec (Canada). Centre de Recherche; Univ. Laval, Quebec, QC (Canada). Centre de Recherche sur le Cancer
Univ. of California, San Francisco, CA (United States)
SLAC National Accelerator Lab., Menlo Park, CA (United States)

The goal of this work is to validate the user-friendly Geant4-based Monte Carlo toolkit TOol for PArticle Simulation (TOPAS) for brachytherapy applications. Brachytherapy simulations performed with TOPAS were systematically compared with published TG-186 reference data. The photon emission energy spectrum, the air-kerma strength, and the dose-rate constant of the model-based dose calculation algorithm (MBDCA)-WG generic Ir-192 source were extracted. For dose calculations, a track-length estimator was implemented. Additionally, the four Joint AAPM/ESTRO/ABG MBDCA-WG test cases were evaluated through histograms of the local and global dose difference volumes. A prostate, a palliative lung, and a breast case were simulated. For each case, the dose ratio map, the histogram of the global dose difference volume, and cumulative dose-volume histograms were calculated. The air-kerma strength was (9.772 ± 0.001) × 10^-8 U Bq^-1 (within 0.3% of the reference value). The dose-rate constant was 1.1107 ± 0.0005 cGy h^-1 U^-1 (within 0.01% of the reference value). For all cases, at least 96.9% of voxels had a local dose difference within [-1%, 1%] and at least 99.9% of voxels had a global dose difference within [-0.1%, 0.1%]. The implemented track-length estimator scorer was more efficient than the default analog dose scorer by a factor of 237. For all clinical cases, at least 97.5% of voxels had a global dose difference within [-1%, 1%]. Dose-volume histograms were consistent with the reference data. TOPAS was validated for high-dose-rate brachytherapy simulations following the TG-186 recommended approach for MBDCAs. Built on top of Geant4, TOPAS provides broad access to a state-of-the-art Monte Carlo code for brachytherapy simulations.

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Research Organization:: SLAC National Accelerator Lab., Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Natural Sciences and Engineering Research Council of Canada (NSERC); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-76SF00515; RGPIN-2019-05038; U24 CA215123

OSTI ID:: 1818227

Journal Information:: Brachytherapy, Vol. 20, Issue 4; ISSN 1538-4721

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (43)

Monte Carlo and experimental dosimetry of an I125 brachytherapy seed: Dosimetry of an I125 brachytherapy seed Dolan, James; Li, Zuofeng; Williamson, Jeffrey F. Medical Physics, Vol. 33, Issue 12 https://doi.org/10.1118/1.2388158	journal	November 2006
Benchmarking BrachyDose: Voxel based EGSnrc Monte Carlo calculations of TG-43 dosimetry parameters: Benchmarking the EGSnrc user-code BrachyDose Taylor, R. E. P.; Yegin, G.; Rogers, D. W. O. Medical Physics, Vol. 34, Issue 2 https://doi.org/10.1118/1.2400843	journal	January 2007
HDRMC, an accelerated Monte Carlo dose calculator for high dose rate brachytherapy with CT-compatible applicators: Brachytherapy Monte Carlo dose calculations Chibani, Omar; C-M Ma, Charlie Medical Physics, Vol. 41, Issue 5 https://doi.org/10.1118/1.4873318	journal	April 2014
Evaluation of high-energy brachytherapy source electronic disequilibrium and dose from emitted electrons: Electronic disequilibrium and electron dose near brachytherapy sources Ballester, Facundo; Granero, Domingo; Pérez-Calatayud, José Medical Physics, Vol. 36, Issue 9Part1 https://doi.org/10.1118/1.3194754	journal	August 2009
A generic high-dose rate ¹⁹² Ir brachytherapy source for evaluation of model-based dose calculations beyond the TG-43 formalism: Model-based dose calculations beyond the TG-43 formalism Ballester, Facundo; Carlsson Tedgren, Åsa; Granero, Domingo Medical Physics, Vol. 42, Issue 6Part1 https://doi.org/10.1118/1.4921020	journal	May 2015
Compute Canada: Advancing Computational Research Baldwin, Susan Journal of Physics: Conference Series, Vol. 341 https://doi.org/10.1088/1742-6596/341/1/012001	journal	February 2012
Initial MCNP6 Release Overview Goorley, T.; James, M.; Booth, T. Nuclear Technology, Vol. 180, Issue 3 https://doi.org/10.13182/NT11-135	journal	December 2012
The evolution of brachytherapy treatment planning: The evolution of brachytherapy treatment planning Rivard, Mark J.; Venselaar, Jack L. M.; Beaulieu, Luc Medical Physics, Vol. 36, Issue 6Part1 https://doi.org/10.1118/1.3125136	journal	May 2009
RapidBrachyMCTPS: a Monte Carlo-based treatment planning system for brachytherapy applications Famulari, Gabriel; Renaud, Marc-André; Poole, Christopher M. Physics in Medicine & Biology, Vol. 63, Issue 17 https://doi.org/10.1088/1361-6560/aad97a	journal	August 2018
Layered mass geometry: a novel technique to overlay seeds and applicators onto patient geometry in Geant4 brachytherapy simulations Enger, Shirin A.; Landry, Guillaume; D'Amours, Michel Physics in Medicine and Biology, Vol. 57, Issue 19 https://doi.org/10.1088/0031-9155/57/19/6269	journal	September 2012
Influence of photon energy spectra from brachytherapy sources on Monte Carlo simulations of kerma and dose rates in water and air: Influence of brachytherapy source photon energy spectra Rivard, Mark J.; Granero, Domingo; Perez-Calatayud, Jose Medical Physics, Vol. 37, Issue 2 https://doi.org/10.1118/1.3298008	journal	January 2010
Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations Rivard, Mark J.; Coursey, Bert M.; DeWerd, Larry A. Medical Physics, Vol. 31, Issue 3 https://doi.org/10.1118/1.1646040	journal	February 2004
A Monte Carlo study on the effect of seed design on the interseed attenuation in permanent prostate implants: Study of seed design on the interseed attenuation Afsharpour, Hossein; D’Amours, Michel; Coté, Benoit Medical Physics, Vol. 35, Issue 8 https://doi.org/10.1118/1.2955754	journal	July 2008
Dosimetric accuracy of a deterministic radiation transport based ¹⁹² Ir brachytherapy treatment planning system. Part III. Comparison to Monte Carlo simulation in voxelized anatomical computational models: BV-Acuros brachytherapy TPS validation using anatomical computational models Zourari, K.; Pantelis, E.; Moutsatsos, A. Medical Physics, Vol. 40, Issue 1 https://doi.org/10.1118/1.4770275	journal	December 2012
Monte Carlo calculations and experimental measurements of dosimetric parameters of the IRA−P103d brachytherapy source: MCNP calculations and experimental measurements IRA−P103d Sadeghi, Mahdi; Raisali, Gholamreza; Hosseini, S. Hamed Medical Physics, Vol. 35, Issue 4 https://doi.org/10.1118/1.2870229	journal	March 2008
Dosimetric performance of Strut-Adjusted Volume Implant: A new single-entry multicatheter breast brachytherapy applicator Gurdalli, Salih; Kuske, Robert R.; Quiet, Coral A. Brachytherapy, Vol. 10, Issue 2 https://doi.org/10.1016/j.brachy.2010.03.002	journal	March 2011
Enhancements to commissioning techniques and quality assurance of brachytherapy treatment planning systems that use model-based dose calculation algorithmsa): Brachytherapy TPS commissioning enhancements for advanced dosimetry Rivard, Mark J.; Beaulieu, Luc; Mourtada, Firas Medical Physics, Vol. 37, Issue 6Part2 https://doi.org/10.1118/1.3429131	journal	May 2010
Optimization of the computational efficiency of a 3D, collapsed cone dose calculation algorithm for brachytherapy: Computational efficiency of collapsed cone dose for brachytherapy Carlsson Tedgren, Åsa; Ahnesjö, Anders Medical Physics, Vol. 35, Issue 4 https://doi.org/10.1118/1.2889777	journal	March 2008
A track length estimator method for dose calculations in low-energy X-ray irradiations: implementation, properties and performance Baldacci, F.; Mittone, A.; Bravin, A. Zeitschrift für Medizinische Physik, Vol. 25, Issue 1 https://doi.org/10.1016/j.zemedi.2014.04.001	journal	March 2015
Dosimetric accuracy of a deterministic radiation transport based I192r brachytherapy treatment planning system. Part II: Monte Carlo and experimental verification of a multiple source dwell position plan employing a shielded applicator: Validation of deterministic radiation transport based treatment planning Petrokokkinos, L.; Zourari, K.; Pantelis, E. Medical Physics, Vol. 38, Issue 4 https://doi.org/10.1118/1.3567507	journal	March 2011
The collapsed cone superposition algorithm applied to scatter dose calculations in brachytherapy Carlsson, Åsa K.; Ahnesjö, Anders Medical Physics, Vol. 27, Issue 10 https://doi.org/10.1118/1.1290485	journal	October 2000
Validation of the Oncentra Brachy Advanced Collapsed cone Engine for a commercial 192Ir source using heterogeneous geometries Ma, Yunzhi; Lacroix, Fréderic; Lavallée, Marie-Claude Brachytherapy, Vol. 14, Issue 6 https://doi.org/10.1016/j.brachy.2015.08.003	journal	November 2015
MCPI©: A sub-minute Monte Carlo dose calculation engine for prostate implants: Prostate implant dose calculations Chibani, Omar; Williamson, Jeffrey F. Medical Physics, Vol. 32, Issue 12 https://doi.org/10.1118/1.2126822	journal	November 2005
Monte Carlo evaluation of kerma at a point for photon transport problems: Monte Carlo calculation of kerma at a point Williamson, Jeffrey F. Medical Physics, Vol. 14, Issue 4 https://doi.org/10.1118/1.596069	journal	July 1987
Dosimetry of interstitial brachytherapy sources: Recommendations of the AAPM Radiation Therapy Committee Task Group No. 43 Nath, Ravinder; Anderson, Lowell L.; Luxton, Gary Medical Physics, Vol. 22, Issue 2 https://doi.org/10.1118/1.597458	journal	February 1995
BrachyGuide: a brachytherapy-dedicated DICOM RT viewer and interface to Monte Carlo simulation software Pantelis, Evaggelos; Peppa, Vassiliki; Lahanas, Vasileios Journal of Applied Clinical Medical Physics, Vol. 16, Issue 1 https://doi.org/10.1120/jacmp.v16i1.5136	journal	January 2015
TOPAS: An innovative proton Monte Carlo platform for research and clinical applications: TOPAS: An innovative proton Monte Carlo platform Perl, J.; Shin, J.; Schümann, J. Medical Physics, Vol. 39, Issue 11 https://doi.org/10.1118/1.4758060	journal	October 2012
Model-Based Dose Calculation Algorithms for Brachytherapy Dosimetry Enger, Shirin A.; Vijande, Javier; Rivard, Mark J. Seminars in Radiation Oncology, Vol. 30, Issue 1 https://doi.org/10.1016/j.semradonc.2019.08.006	journal	January 2020
A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate ¹⁹² Ir brachytherapy Ma, Yunzhi; Vijande, Javier; Ballester, Facundo Medical Physics, Vol. 44, Issue 11 https://doi.org/10.1002/mp.12459	journal	October 2017
Comparison of a finite-element multigroup discrete-ordinates code with Monte Carlo for radiotherapy calculations Gifford, Kent A.; Horton, John L.; Wareing, Todd A. Physics in Medicine and Biology, Vol. 51, Issue 9 https://doi.org/10.1088/0031-9155/51/9/010	journal	April 2006
Collapsed cone convolution of radiant energy for photon dose calculation in heterogeneous media: Photon dose calculation Ahnesjö, Anders Medical Physics, Vol. 16, Issue 4 https://doi.org/10.1118/1.596360	journal	July 1989
The effect of finite patient dimensions and tissue inhomogeneities on dosimetry planning of 192Ir HDR breast brachytherapy: A Monte Carlo dose verification study Pantelis, Evaggelos; Papagiannis, Panagiotis; Karaiskos, Pantelis International Journal of Radiation OncologyBiologyPhysics, Vol. 61, Issue 5 https://doi.org/10.1016/j.ijrobp.2004.12.065	journal	April 2005
The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research Faddegon, Bruce; Ramos-Méndez, José; Schuemann, Jan Physica Medica, Vol. 72 https://doi.org/10.1016/j.ejmp.2020.03.019	journal	April 2020
Optimization of deterministic transport parameters for the calculation of the dose distribution around a high dose-rate I192r brachytherapy source: Optimization of deterministic I192r calculations Gifford, Kent A.; Price, Michael J.; Horton, John L. Medical Physics, Vol. 35, Issue 6Part1 https://doi.org/10.1118/1.2919074	journal	May 2008
Report of the Task Group 186 on model-based dose calculation methods in brachytherapy beyond the TG-43 formalism: Current status and recommendations for clinical implementation: TG-186: Model-based dose calculation techniques in brachytherapy Beaulieu, Luc; Carlsson Tedgren, Åsa; Carrier, Jean-François Medical Physics, Vol. 39, Issue 10 https://doi.org/10.1118/1.4747264	journal	September 2012
Dose calculation for photon-emitting brachytherapy sources with average energy higher than 50 keV: Report of the AAPM and ESTRO: High-energy photon-emitting brachytherapy dosimetry Perez-Calatayud, Jose; Ballester, Facundo; Das, Rupak K. Medical Physics, Vol. 39, Issue 5 https://doi.org/10.1118/1.3703892	journal	May 2012
Geant4—a simulation toolkit Agostinelli, S.; Allison, J.; Amako, K. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 506, Issue 3 https://doi.org/10.1016/S0168-9002(03)01368-8	journal	July 2003
Dosimetric impact of an I192r brachytherapy source cable length modeled using a grid-based Boltzmann transport equation solver: Dosimetric impact of an I192r brachytherapy source cable Mikell, Justin K.; Mourtada, Firas Medical Physics, Vol. 37, Issue 9 https://doi.org/10.1118/1.3478278	journal	August 2010
ALGEBRA: ALgorithm for the heterogeneous dosimetry based on GEANT4 for BRAchytherapy Afsharpour, H.; Landry, G.; D’Amours, M. Physics in Medicine and Biology, Vol. 57, Issue 11 https://doi.org/10.1088/0031-9155/57/11/3273	journal	May 2012
Dosimetric accuracy of a deterministic radiation transport based I192r brachytherapy treatment planning system. Part I: Single sources and bounded homogeneous geometries: Validation of deterministic radiation transport based treatment planning Zourari, K.; Pantelis, E.; Moutsatsos, A. Medical Physics, Vol. 37, Issue 2 https://doi.org/10.1118/1.3290630	journal	January 2010
egs_brachy: a versatile and fast Monte Carlo code for brachytherapy Chamberland, Marc J. P.; Taylor, Randle E. P.; Rogers, D. W. O. Physics in Medicine and Biology, Vol. 61, Issue 23 https://doi.org/10.1088/0031-9155/61/23/8214	journal	November 2016
On the Dosimetric Effect of Heterogeneities and Finite Patient Dimensions on 60CO HDR Brachytherapy Zourari, Kyveli; Pantelis, Evangelos; Papagiannis, Panagiotis Brachytherapy, Vol. 15 https://doi.org/10.1016/j.brachy.2016.04.033	journal	May 2016
Fifty years of Monte Carlo simulations for medical physics Rogers, D. W. O. Physics in Medicine and Biology, Vol. 51, Issue 13 https://doi.org/10.1088/0031-9155/51/13/R17	journal	June 2006

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