DNA-PK, ATM and ATR collaboratively regulate p53–RPA interaction to facilitate homologous recombination DNA repair
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journal
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July 2012 |
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN
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September 2017 |
The DNA Damage Response: Making It Safe to Play with Knives
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October 2010 |
Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function
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journal
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March 2016 |
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
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journal
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September 2008 |
CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation
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journal
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October 2010 |
CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression
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December 2013 |
CRL4ACRBN E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis
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May 2014 |
Non-homologous DNA end joining and alternative pathways to double-strand break repair
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journal
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May 2017 |
CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis
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May 2009 |
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair
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journal
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March 2018 |
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus
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journal
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December 1997 |
Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
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journal
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April 2009 |
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
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journal
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March 1999 |
Study of the G2/M cell cycle checkpoint in irradiated mammary epithelial cells overexpressing Cul-4A gene
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journal
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March 2002 |
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs
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journal
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November 2004 |
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
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journal
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June 2010 |
Non-homologous DNA end joining.
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journal
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December 2003 |
Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines
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journal
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November 2018 |
In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis
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journal
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October 2008 |
Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis
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journal
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June 2006 |
BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
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journal
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November 2017 |
DNA-PK as an Emerging Therapeutic Target in Cancer
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journal
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July 2019 |
LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair
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journal
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October 2015 |
MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers
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journal
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August 2019 |
The role of DNA breaks in genomic instability and tumorigenesis: Mills et al · DNA breaks, translocations, and tumor formation
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journal
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July 2003 |
CRL4Wdr70 regulates H2B monoubiquitination and facilitates Exo1-dependent resection
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journal
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April 2016 |
DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis
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journal
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July 2015 |
C/EBPα regulates CRL4 Cdt2 -mediated degradation of p21 in response to UVB-induced DNA damage to control the G 1 /S checkpoint
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journal
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October 2014 |
Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis
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journal
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July 2008 |
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation
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journal
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March 2010 |
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86
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journal
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August 2009 |
Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage
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journal
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November 2010 |
Cul4A and DDB1 Associate with Skp2 To Target p27 Kip1 for Proteolysis Involving the COP9 Signalosome
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journal
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April 2006 |
ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice
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journal
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December 2017 |
CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1 Cdt2 Pathway during S Phase and after UV Irradiation
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journal
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August 2008 |
Role of genomic instability in human carcinogenesis
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journal
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February 2019 |
The COP9 signalosome is vital for timely repair of DNA double-strand breaks
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journal
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April 2015 |
Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis
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journal
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February 1999 |
Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2
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journal
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April 2014 |
DNA and chromosome damage induced by bleomycin in mammalian cells: An update
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journal
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January 2018 |
Cdt2-mediated XPG degradation promotes gap-filling DNA synthesis in nucleotide excision repair
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journal
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April 2015 |
Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4 DDB2 E3 Ligase
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journal
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May 2016 |
Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics
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journal
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February 2013 |
CRL1-FBXO11 Promotes Cdt2 Ubiquitylation and Degradation and Regulates Pr-Set7/Set8-Mediated Cellular Migration
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journal
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March 2013 |
DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress
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journal
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March 2009 |
Oncogenic CUL4A determines the response to thalidomide treatment in prostate cancer
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journal
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March 2012 |
Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM
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journal
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January 2017 |
A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-Off during Nucleosome Assembly
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journal
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November 2013 |
High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde
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journal
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January 2011 |
CRL4 Cdt2: Master coordinator of cell cycle progression and genome stability
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journal
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January 2011 |
L2DTL/CDT2 Interacts with the CUL4/DDB1 Complex and PCNA and Regulates CDT1 Proteolysis in Response to DNA Damage
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journal
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July 2006 |
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair
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journal
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December 2017 |
BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle
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journal
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September 2014 |
Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint
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journal
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October 2003 |
FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair
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journal
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June 2016 |
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4
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journal
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February 2016 |
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
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journal
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February 2017 |
A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1
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journal
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September 2006 |
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
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journal
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June 2008 |
PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
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journal
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March 2020 |
DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase
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journal
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June 2007 |