NEDD8 Pathways in Cancer, Sine Quibus Non
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journal
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February 2011 |
Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase
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June 2017 |
Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8
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June 2014 |
Targeted Covalent Inhibitors for Drug Design
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August 2016 |
Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy
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December 2014 |
Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a ]pyrimidine-Based Inhibitors Targeting the DCN1–UBC12 Protein–Protein Interaction
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February 2019 |
Discovery of Novel Pyrazolo-pyridone DCN1 Inhibitors Controlling Cullin Neddylation
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August 2019 |
Cullin-RING Ligases as Attractive Anti-cancer Targets
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April 2013 |
Proteasome inhibitors in cancer therapy
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January 2017 |
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy
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July 2010 |
MolProbity : all-atom structure validation for macromolecular crystallography
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December 2009 |
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization
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September 2004 |
Features and development of Coot
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March 2010 |
Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
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December 2010 |
N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex
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September 2011 |
Function and regulation of cullin–RING ubiquitin ligases
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January 2005 |
Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ
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journal
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January 2010 |
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
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journal
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July 2013 |
Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation
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March 2018 |
NRF2 and the Hallmarks of Cancer
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July 2018 |
Protein neddylation and its alterations in human cancers for targeted therapy
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April 2018 |
A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation
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journal
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October 2017 |
Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)
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journal
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August 2013 |
Drug discovery in the ubiquitin–proteasome system
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July 2006 |
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction
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May 2019 |
Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present)
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February 2020 |
Molecular replacement with MOLREP
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journal
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December 2009 |
Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer
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journal
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June 2009 |
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
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journal
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September 2004 |
The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle
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journal
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August 2005 |
Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation
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journal
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March 2018 |
Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity
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journal
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February 2005 |
High-Affinity Peptidomimetic Inhibitors of the DCN1-UBC12 Protein–Protein Interaction
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January 2018 |
Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation
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April 2015 |
The Keap1–Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases
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December 2016 |
The ubiquitin-proteasome pathway: The complexity and myriad functions of proteins death
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March 1998 |
6-Substituted-4-(3-bromophenylamino)quinazolines as Putative Irreversible Inhibitors of the Epidermal Growth Factor Receptor (EGFR) and Human Epidermal Growth Factor Receptor (HER-2) Tyrosine Kinases with Enhanced Antitumor Activity
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August 2001 |
Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation
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January 2008 |
The resurgence of covalent drugs
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April 2011 |
Drug discovery considerations in the development of covalent inhibitors
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January 2014 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
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January 2019 |
A Dual E3 Mechanism for Rub1 Ligation to Cdc53
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journal
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September 2010 |
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
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journal
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September 2008 |
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
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journal
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June 2005 |
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
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April 2009 |