Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger
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August 1997 |
Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers
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August 2013 |
Raf-1 Cysteine-Rich Domain Increases the Affinity of K-Ras/Raf at the Membrane, Promoting MAPK Signaling
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March 2018 |
Collaboration gets the most out of software
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September 2013 |
14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity
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September 1998 |
Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes
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October 2019 |
Inhibition of RAS function through targeting an allosteric regulatory site
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November 2016 |
Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring
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February 2020 |
Ras Interaction with Two Distinct Binding Domains in Raf-1 5 Be Required for Ras Transformation
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January 1996 |
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
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February 2018 |
NMR Characterization of Full-length Farnesylated and Non-farnesylated H-Ras and its Implications for Raf Activation
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November 2004 |
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design
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July 2016 |
Elucidation of Binding Determinants and Functional Consequences of Ras/Raf-Cysteine-rich Domain Interactions
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April 2000 |
Structural Determinants of Ras-Raf Interaction Analyzed in Live Cells
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July 2002 |
Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
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September 2014 |
XDS
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January 2010 |
Structures of N-terminally processed KRAS provide insight into the role of N-acetylation
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July 2019 |
Regulation of RAF protein kinases in ERK signalling
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April 2015 |
Regulation and Role of Raf-1/B-Raf Heterodimerization
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March 2006 |
SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis
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October 2018 |
The Strength of Interaction at the Raf Cysteine-Rich Domain Is a Critical Determinant of Response of Raf to Ras Family Small GTPases
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September 1999 |
Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization
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January 2020 |
Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
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September 2019 |
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo
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March 1996 |
Autoregulation of the Raf-1 serine/threonine kinase
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August 1998 |
Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane
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May 2020 |
Deciphering key features in protein structures with the new ENDscript server
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April 2014 |
The Frequency of Ras Mutations in Cancer
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March 2020 |
Features and development of Coot
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March 2010 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions
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December 2016 |
Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega
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January 2011 |
Two Distinct Raf Domains Mediate Interaction with Ras
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April 1995 |
Cysteine-rich Region of Raf-1 Interacts with Activator Domain of Post-translationally Modified Ha-Ras
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December 1995 |
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
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December 2018 |
The RafC1 Cysteine-Rich Domain Contains Multiple Distinct Regulatory Epitopes Which Control Ras-Dependent Raf Activation
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November 1998 |
Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD
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March 2015 |
Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate
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June 2004 |
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: Molecular diversity and associated phenotypic spectrum
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April 2009 |
A “Tug of War” Maintains a Dynamic Protein–Membrane Complex: Molecular Dynamics Simulations of C-Raf RBD-CRD Bound to K-Ras4B at an Anionic Membrane
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February 2018 |
The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site.
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August 1996 |
Ras/Rap effector specificity determined by charge reversal
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August 1996 |
The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling
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March 2020 |
The RAF proteins take centre stage
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November 2004 |
Phaser crystallographic software
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July 2007 |
VMD: Visual molecular dynamics
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February 1996 |
Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain
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May 2018 |
The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras
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April 1994 |