Influence of External NaCl Salt on Membrane Rigidity of Neutral DOPC Vesicles

De Mel, Judith U.; Gupta, Sudipta; Perera, Rasangi M.; Ngo, Ly; Zolnierczuk, Piotr; Bleuel, Markus; Pingali, Sai Venkatesh; Schneider, Gerald J.

doi:10.1021/acs.langmuir.0c01004

Title: Influence of External NaCl Salt on Membrane Rigidity of Neutral DOPC Vesicles

Journal Article · Thu Jul 16 00:00:00 EDT 2020 · Langmuir

DOI:https://doi.org/10.1021/acs.langmuir.0c01004· OSTI ID:1673770

^[1];

^[1]; Perera, Rasangi M. ^[1]; Ngo, Ly ^[1]; Zolnierczuk, Piotr ^[2]; Bleuel, Markus ^[3];

^[4];

^[1]

Louisiana State Univ., Baton Rouge, LA (United States)
Jülich Centre for Neutron Science (JCNS), Oak Ridge, TN (United States)
National Inst. of Standards and Technology (NIST), Gaithersburg, MD (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sodium chloride (NaCl) is a very common molecule in biotic and abiotic aqueous environments. In both cases, variation of ionic strength is inevitable. In addition to the osmotic variation posed by such perturbations, the question of whether the interactions of monovalent ions Na+ and Cl–, especially with the neutral head groups of phospholipid membranes are impactful enough to change the membrane rigidity, is still not entirely understood. We investigated the dynamics of 1,2-di-(octadecenoyl)-sn-glycero-3-phosphocholine (DOPC) vesicles with zwitterionic neutral head groups in the fluid phase with increasing external salt concentration. At higher salt concentrations, we observe an increase in bending rigidity from neutron spin echo (NSE) spectroscopy and an increase in bilayer thickness from small-angle X-ray scattering (SAXS). We compared different models to distinguish membrane undulations, lipid tail motions, and the translational diffusion of the vesicles. All of the models indicate an increase in bending rigidity by a factor of 1.3–3.6. We demonstrate that even down to t > 10 ns and for Q > 0.07 Å–1, the observed NSE relaxation spectra are influenced by translational diffusion of the vesicles. For t < 5 ns, the lipid tail motion dominates the intermediate dynamic structure factor. As the salt concentration increases, this contribution diminishes. We introduced a time-dependent analysis for the bending rigidity that highlights only a limited Zilman–Granek time window in which the rigidity is physically meaningful.

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Research Organization:: Louisiana State Univ., Baton Rouge, LA (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0012432; AC05-00OR22725

OSTI ID:: 1673770

Alternate ID(s):: OSTI ID: 1959643

Journal Information:: Langmuir, Vol. 36, Issue 32; ISSN 0743-7463

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

References (74)

Rigidification of Neutral Lipid Bilayers in the Presence of Salts Pabst, Georg; Hodzic, Aden; Štrancar, Janez Biophysical Journal, Vol. 93, Issue 8 https://doi.org/10.1529/biophysj.107.112615	journal	October 2007
Effects of Lithium and Other Monovalent Ions on Palmitoyl Oleoyl Phosphatidylcholine Bilayer Kruczek, James; Chiu, See-Wing; Jakobsson, Eric Langmuir, Vol. 33, Issue 4 https://doi.org/10.1021/acs.langmuir.6b04166	journal	January 2017
Effects of sodium chloride on membrane fusion and on the formation of aggregates of potassium channel KcsA in Escherichia coli membrane Raja, Mobeen; Vales, Elisabeth Biophysical Chemistry, Vol. 142, Issue 1-3 https://doi.org/10.1016/j.bpc.2009.03.005	journal	June 2009
Salt-Triggered Intermembrane Exchange of Phospholipids and Hemifusion by Myelin Basic Protein Cajal, Yolanda; Boggs, Joan M.; Jain, Mahendra K. Biochemistry, Vol. 36, Issue 9 https://doi.org/10.1021/bi962232+	journal	March 1997
Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress Nunes, Paula; Roth, Isabelle; Meda, Paolo Proceedings of the National Academy of Sciences, Vol. 112, Issue 24 https://doi.org/10.1073/pnas.1421290112	journal	June 2015
Binding of alkaline-earth metal cations and some anions to hosphatidylcholine liposomes Tatulian, Suren A. European Journal of Biochemistry, Vol. 170, Issue 1-2 https://doi.org/10.1111/j.1432-1033.1987.tb13715.x	journal	December 1987
The effect of metal cations on the phase behavior and hydration characteristics of phospholipid membranes Binder, Hans; Zschörnig, Olaf Chemistry and Physics of Lipids, Vol. 115, Issue 1-2 https://doi.org/10.1016/S0009-3084(02)00005-1	journal	May 2002
Membrane tension homeostasis of epithelial cells through surface area regulation in response to osmotic stress Pietuch, Anna; Brückner, Bastian R.; Janshoff, Andreas Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1833, Issue 3 https://doi.org/10.1016/j.bbamcr.2012.11.006	journal	March 2013
Membrane fluidity and its roles in the perception of environmental signals Los, Dmitry A.; Murata, Norio Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1666, Issue 1-2 https://doi.org/10.1016/j.bbamem.2004.08.002	journal	November 2004
Bacterial Osmoregulation: A Paradigm for the Study of Cellular Homeostasis Wood, Janet M. Annual Review of Microbiology, Vol. 65, Issue 1 https://doi.org/10.1146/annurev-micro-090110-102815	journal	October 2011
Bacterial osmosensing: roles of membrane structure and electrostatics in lipid–protein and protein–protein interactions Poolman, Bert; Spitzer, Jan J.; Wood, Janet M. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1666, Issue 1-2 https://doi.org/10.1016/j.bbamem.2004.06.013	journal	November 2004
Swelling of phospholipids by monovalent salt Petrache, Horia I.; Tristram-Nagle, Stephanie; Harries, Daniel Journal of Lipid Research, Vol. 47, Issue 2 https://doi.org/10.1194/jlr.M500401-JLR200	journal	November 2005
Mixing Water, Transducing Energy, and Shaping Membranes: Autonomously Self-Regulating Giant Vesicles Ho, James C. S.; Rangamani, Padmini; Liedberg, Bo Langmuir, Vol. 32, Issue 9 https://doi.org/10.1021/acs.langmuir.5b04470	journal	February 2016
Pulsatile Lipid Vesicles under Osmotic Stress Chabanon, Morgan; Ho, James C. S.; Liedberg, Bo Biophysical Journal, Vol. 112, Issue 8 https://doi.org/10.1016/j.bpj.2017.03.018	journal	April 2017
Effects of Monovalent Anions of the Hofmeister Series on DPPC Lipid Bilayers Part I: Swelling and In-Plane Equations of State Aroti, A.; Leontidis, E.; Dubois, M. Biophysical Journal, Vol. 93, Issue 5 https://doi.org/10.1529/biophysj.106.094482	journal	September 2007
Effect of lipid phase transition on the binding of anions to dimyristoylphosphatidylcholine liposomes Tatulian, Suren A. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 736, Issue 2 https://doi.org/10.1016/0005-2736(83)90283-3	journal	December 1983
The Hypotonic Environmental Changes Affect Liposomal Formulations for Nose-to-Brain Targeted Drug Delivery Wu, Iren Yeeling; Nikolaisen, Trygg Einar; Škalko-Basnet, Nataša Journal of Pharmaceutical Sciences, Vol. 108, Issue 8 https://doi.org/10.1016/j.xphs.2019.03.006	journal	August 2019
Influence of the environmental tonicity perturbations on the release of model compounds from large unilamellar vesicles (LUVs): A mechanistic investigation Wu, Iren Yeeling; Škalko-Basnet, Nataša; di Cagno, Massimiliano Pio Colloids and Surfaces B: Biointerfaces, Vol. 157 https://doi.org/10.1016/j.colsurfb.2017.05.062	journal	September 2017
Osmotically Induced Membrane Tension Modulates Membrane Permeabilization by Class L Amphipathic Helical Peptides: Nucleation Model of Defect Formation Polozov, I. V.; Anantharamaiah, G. M.; Segrest, J. P. Biophysical Journal, Vol. 81, Issue 2 https://doi.org/10.1016/S0006-3495(01)75753-0	journal	August 2001
Charged Lipid Vesicles: Effects of Salts on Bending Rigidity, Stability, and Size Claessens, M. M. A. E.; van Oort, B. F.; Leermakers, F. A. M. Biophysical Journal, Vol. 87, Issue 6 https://doi.org/10.1529/biophysj.103.036772	journal	December 2004
Surface changes induced by osmotic shrinkage on large unilamellar vesicles Disalvo, E. A.; Campos, A. M.; Abuin, E. Chemistry and Physics of Lipids, Vol. 84, Issue 1, p. 35-45 https://doi.org/10.1016/S0009-3084(96)02617-5	journal	November 1996
Buffers Affect the Bending Rigidity of Model Lipid Membranes Bouvrais, Hélène; Duelund, Lars; Ipsen, John H. Langmuir, Vol. 30, Issue 1 https://doi.org/10.1021/la403565f	journal	December 2013
Salt Tolerance of Archaeal Extremely Halophilic Lipid Membranes Tenchov, Boris; Vescio, Erin M.; Sprott, G. Dennis Journal of Biological Chemistry, Vol. 281, Issue 15 https://doi.org/10.1074/jbc.M600369200	journal	April 2006
Bending rigidity of charged lipid bilayer membranes Faizi, Hammad A.; Frey, Shelli L.; Steinkühler, Jan Soft Matter, Vol. 15, Issue 29 https://doi.org/10.1039/C9SM00772E	journal	January 2019
Effect of pressure on membranes Winter, Roland; Jeworrek, Christoph Soft Matter, Vol. 5, Issue 17 https://doi.org/10.1039/b901690b	journal	January 2009
Effect of NaCl and KCl on Phosphatidylcholine and Phosphatidylethanolamine Lipid Membranes: Insight from Atomic-Scale Simulations for Understanding Salt-Induced Effects in the Plasma Membrane Gurtovenko, Andrey A.; Vattulainen, Ilpo The Journal of Physical Chemistry B, Vol. 112, Issue 7 https://doi.org/10.1021/jp0750708	journal	February 2008
Changes in Phosphatidylcholine Headgroup Tilt and Water Order Induced by Monovalent Salts: Molecular Dynamics Simulations Sachs, Jonathan N.; Nanda, Hirsh; Petrache, Horia I. Biophysical Journal, Vol. 86, Issue 6 https://doi.org/10.1529/biophysj.103.035816	journal	June 2004
Specific Binding of Chloride Ions to Lipid Vesicles and Implications at Molecular Scale Knecht, Volker; Klasczyk, Benjamin Biophysical Journal, Vol. 104, Issue 4 https://doi.org/10.1016/j.bpj.2012.12.056	journal	February 2013
Saturation of charge-induced water alignment at model membrane surfaces Dreier, Lisa B.; Nagata, Yuki; Lutz, Helmut Science Advances, Vol. 4, Issue 3 https://doi.org/10.1126/sciadv.aap7415	journal	March 2018
Interaction of Small Ionic Species With Phospholipid Membranes: The Role of Metal Coordination Le, Chanh Thi Minh; Houri, Aamd; Balage, Nimalka Frontiers in Materials, Vol. 5 https://doi.org/10.3389/fmats.2018.00080	journal	January 2019
Salt-induced effects on natural and inverse DPPC lipid membranes: Molecular dynamics simulation Rezaei Sani, Seyed Mojtaba; Akhavan, Mojdeh; Jalili, Seifollah Biophysical Chemistry, Vol. 239 https://doi.org/10.1016/j.bpc.2018.04.006	journal	August 2018
Asymmetry of lipid bilayers induced by monovalent salt: Atomistic molecular-dynamics study Gurtovenko, Andrey A. The Journal of Chemical Physics, Vol. 122, Issue 24 https://doi.org/10.1063/1.1942489	journal	June 2005
Effect of Sodium and Chloride Binding on a Lecithin Bilayer. A Molecular Dynamics Study Reif, Maria; Kallies, Christopher; Knecht, Volker Membranes, Vol. 7, Issue 1 https://doi.org/10.3390/membranes7010005	journal	January 2017
Lipid map of the mammalian cell van Meer, G.; de Kroon, A. I. P. M. Journal of Cell Science, Vol. 124, Issue 1 https://doi.org/10.1242/jcs.071233	journal	December 2010
Lipid Organization of the Plasma Membrane Ingólfsson, Helgi I.; Melo, Manuel N.; van Eerden, Floris J. Journal of the American Chemical Society, Vol. 136, Issue 41 https://doi.org/10.1021/ja507832e	journal	October 2014
The Bio-SANS instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory Heller, William T.; Urban, Volker S.; Lynn, Gary W. Journal of Applied Crystallography, Vol. 47, Issue 4 https://doi.org/10.1107/S1600576714011285	journal	June 2014
SAXS experiments on absolute scale with Kratky systems using water as a secondary standard Orthaber, Doris; Bergmann, Alexander; Glatter, Otto Journal of Applied Crystallography, Vol. 33, Issue 2 https://doi.org/10.1107/S0021889899015216	journal	April 2000
The spin-echo spectrometer at the Spallation Neutron Source (SNS) Ohl, M.; Monkenbusch, M.; Arend, N. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 696 https://doi.org/10.1016/j.nima.2012.08.059	journal	December 2012
DAVE: A Comprehensive Software Suite for the Reduction, Visualization, and Analysis of Low Energy Neutron Spectroscopic Data Azuah, Richard Tumanjong; Kneller, Larry R.; Qiu, Yiming Journal of Research of the National Institute of Standards and Technology, Vol. 114, Issue 6 https://doi.org/10.6028/jres.114.025	journal	November 2009
Hydration of DOPC bilayers by differential scanning calorimetry Ulrich, Anne S.; Sami, Malkit; Watts, Anthony Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1191, Issue 1 https://doi.org/10.1016/0005-2736(94)90253-4	journal	April 1994
Modelling X-ray or neutron scattering spectra of lyotropic lamellar phases : interplay between form and structure factors Nallet, F.; Laversanne, R.; Roux, D. Journal de Physique II, Vol. 3, Issue 4 https://doi.org/10.1051/jp2:1993146	journal	April 1993
Influence of Water-Soluble Polymers on the Shear-Induced Structure Formation in Lyotropic Lamellar Phases Berghausen, Jörg; Zipfel, Johannes; Lindner, Peter The Journal of Physical Chemistry B, Vol. 105, Issue 45 https://doi.org/10.1021/jp0115897	journal	November 2001
Dynamic phase diagram of soft nanocolloids Gupta, Sudipta; Camargo, Manuel; Stellbrink, Jörg Nanoscale, Vol. 7, Issue 33 https://doi.org/10.1039/C5NR03702F	journal	January 2015
Dynamics of Phospholipid Membranes beyond Thermal Undulations Gupta, Sudipta; De Mel, Judith U.; Perera, Rasangi M. The Journal of Physical Chemistry Letters, Vol. 9, Issue 11 https://doi.org/10.1021/acs.jpclett.8b01008	journal	May 2018
Softening of phospholipid membranes by the adhesion of silica nanoparticles – as seen by neutron spin-echo (NSE) Hoffmann, Ingo; Michel, Raphael; Sharp, Melissa Nanoscale, Vol. 6, Issue 12 https://doi.org/10.1039/C4NR00774C	journal	January 2014
Lipid Bilayers and Membrane Dynamics: Insight into Thickness Fluctuations Woodka, Andrea C.; Butler, Paul D.; Porcar, Lionel Physical Review Letters, Vol. 109, Issue 5 https://doi.org/10.1103/PhysRevLett.109.058102	journal	July 2012
Mechanical Properties of Nanoscopic Lipid Domains Nickels, Jonathan D.; Cheng, Xiaolin; Mostofian, Barmak Journal of the American Chemical Society, Vol. 137, Issue 50 https://doi.org/10.1021/jacs.5b08894	journal	October 2015
Modeling the dynamics of phospholipids in the fluid phase of liposomes Gupta, Sudipta; Schneider, Gerald J. Soft Matter, Vol. 16, Issue 13 https://doi.org/10.1039/C9SM02111F	journal	January 2020
Undulations and Dynamic Structure Factor of Membranes Zilman, A. G.; Granek, R. Physical Review Letters, Vol. 77, Issue 23 https://doi.org/10.1103/PhysRevLett.77.4788	journal	December 1996
Interpreting Membrane Scattering Experiments at the Mesoscale: The Contribution of Dissipation within the Bilayer Watson, Max C.; Brown, Frank L. H. Biophysical Journal, Vol. 98, Issue 6 https://doi.org/10.1016/j.bpj.2009.11.026	journal	March 2010
Probing Elastic and Viscous Properties of Phospholipid Bilayers Using Neutron Spin Echo Spectroscopy Nagao, Michihiro; Kelley, Elizabeth G.; Ashkar, Rana The Journal of Physical Chemistry Letters, Vol. 8, Issue 19 https://doi.org/10.1021/acs.jpclett.7b01830	journal	September 2017
Neutron spin–echo investigations of membrane undulations in complex fluids involving amphiphiles Takeda, T.; Kawabata, Y.; Seto, H. Journal of Physics and Chemistry of Solids, Vol. 60, Issue 8-9 https://doi.org/10.1016/S0022-3697(99)00122-5	journal	September 1999
Dynamics of liposomes in the fluid phase Gupta, Sudipta; De Mel, Judith U.; Schneider, Gerald J. Current Opinion in Colloid & Interface Science, Vol. 42 https://doi.org/10.1016/j.cocis.2019.05.003	journal	August 2019
Quasielastic Neutron Scattering Study on the Dynamics of Poly(alkylene oxide)s Gerstl, C.; Schneider, G. J.; Fuxman, A. Macromolecules, Vol. 45, Issue 10 https://doi.org/10.1021/ma3003399	journal	May 2012
Anomalous chain diffusion in unentangled model polymer nanocomposites Schneider, Gerald J.; Nusser, Klaus; Neueder, Susanne Soft Matter, Vol. 9, Issue 16 https://doi.org/10.1039/c3sm27886g	journal	January 2013
Protein Crowding in Lipid Bilayers Gives Rise to Non-Gaussian Anomalous Lateral Diffusion of Phospholipids and Proteins Jeon, Jae-Hyung; Javanainen, Matti; Martinez-Seara, Hector Physical Review X, Vol. 6, Issue 2 https://doi.org/10.1103/PhysRevX.6.021006	journal	April 2016
Structural and mechanical properties of cardiolipin lipid bilayers determined using neutron spin echo, small angle neutron and X-ray scattering, and molecular dynamics simulations Pan, Jianjun; Cheng, Xiaolin; Sharp, Melissa Soft Matter, Vol. 11, Issue 1 https://doi.org/10.1039/C4SM02227K	journal	January 2015
Structure of lipid bilayers Nagle, John F.; Tristram-Nagle, Stephanie Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, Vol. 1469, Issue 3 https://doi.org/10.1016/S0304-4157(00)00016-2	journal	November 2000
Structural changes in dipalmitoylphosphatidylcholine bilayer promoted by Ca2+ ions: a small-angle neutron scattering study Uhríková, Daniela; Kučerka, Norbert; Teixeira, José Chemistry and Physics of Lipids, Vol. 155, Issue 2 https://doi.org/10.1016/j.chemphyslip.2008.07.010	journal	October 2008
Structure and order in lamellar phases determined by small-angle scattering Frühwirth, Thomas; Fritz, Gerhard; Freiberger, Norbert Journal of Applied Crystallography, Vol. 37, Issue 5 https://doi.org/10.1107/S0021889804012956	journal	September 2004
Temperature Dependence of Structure, Bending Rigidity, and Bilayer Interactions of Dioleoylphosphatidylcholine Bilayers Pan, Jianjun; Tristram-Nagle, Stephanie; Kučerka, Norbert Biophysical Journal, Vol. 94, Issue 1 https://doi.org/10.1529/biophysj.107.115691	journal	January 2008
Effects of cations on dipalmitoyl phosphatidylcholine/cholesterol/water systems Inoko, Yōji; Yamaguchi, Takashi; Furuya, Kishio Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 413, Issue 1 https://doi.org/10.1016/0005-2736(75)90055-3	journal	November 1975
SAXS, SANS and NSE Studies on “Unbound State” in DPPC/Water/CaCl ₂ System L. Yamada, Norifumi; Seto, Hideki; Takeda, Takayoshi Journal of the Physical Society of Japan, Vol. 74, Issue 10 https://doi.org/10.1143/JPSJ.74.2853	journal	October 2005
Thermal-mechanical fluctuations of fluid membranes in confined geometries: the case of soft confinement Podgornik, Rudi; Parsegian, V. Adrian Langmuir, Vol. 8, Issue 2 https://doi.org/10.1021/la00038a041	journal	February 1992
Non-Gaussian Fluctuations Resulting from Power-Law Trapping in a Lipid Bilayer Akimoto, Takuma; Yamamoto, Eiji; Yasuoka, Kenji Physical Review Letters, Vol. 107, Issue 17 https://doi.org/10.1103/PhysRevLett.107.178103	journal	October 2011
Multiscale mode dynamics of a tethered membrane Pandey, R. B.; Anderson, Kelly L.; Farmer, B. L. Physical Review E, Vol. 75, Issue 6 https://doi.org/10.1103/PhysRevE.75.061913	journal	June 2007
A molecular dynamics study of the breathing and deforming modes of the spherical ionic SDS and nonionic C12E8 micelles Wang, Lin; Fujimoto, Kazushi; Yoshii, Noriyuki The Journal of Chemical Physics, Vol. 144, Issue 3 https://doi.org/10.1063/1.4940031	journal	January 2016
Spherical harmonics analysis of surface density fluctuations of spherical ionic SDS and nonionic C12E8 micelles: A molecular dynamics study Yoshii, Noriyuki; Nimura, Yuki; Fujimoto, Kazushi The Journal of Chemical Physics, Vol. 147, Issue 3 https://doi.org/10.1063/1.4994698	journal	July 2017
Bending elasticity of saturated and monounsaturated phospholipid membranes studied by the neutron spin echo technique Yi, Zheng; Nagao, Michihiro; Bossev, Dobrin P. Journal of Physics: Condensed Matter, Vol. 21, Issue 15 https://doi.org/10.1088/0953-8984/21/15/155104	journal	March 2009
Introductory Lecture: Basic quantities in model biomembranes Nagle, John F. Faraday Discuss., Vol. 161 https://doi.org/10.1039/C2FD20121F	journal	January 2013
Bending elasticity of electrically charged bilayers: coupled monolayers, neutral surfaces, and balancing stresses Winterhalter, M.; Helfrich, W. The Journal of Physical Chemistry, Vol. 96, Issue 1 https://doi.org/10.1021/j100180a060	journal	January 1992
Electrostatic rigidity of charged membranes in systems without added salt Fogden, A.; Daicic, J.; Mitchell, D. J. Physica A: Statistical Mechanics and its Applications, Vol. 234, Issue 1-2 https://doi.org/10.1016/S0378-4371(96)00278-6	journal	December 1996
Electrostatic Interactions, Curvature Elasticity, and Steric Repulsion in Multimembrane Systems Pincus, P.; Joanny, J. -F; Andelman, D. Europhysics Letters (EPL), Vol. 11, Issue 8 https://doi.org/10.1209/0295-5075/11/8/012	journal	April 1990
Membrane curvature elasticity in weakly charged lamellar phases Harden, J. L.; Marques, C.; Joanny, J. F. Langmuir, Vol. 8, Issue 4 https://doi.org/10.1021/la00040a025	journal	April 1992

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Stiffness
Salts
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Title: Influence of External NaCl Salt on Membrane Rigidity of Neutral DOPC Vesicles

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