NAD(P) Biosynthesis Enzymes as Potential Targets for Selective Drug Design
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April 2009 |
Detection of Transient Intermediates in the Metal-Dependent Nonoxidative Decarboxylation Catalyzed by α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase
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August 2007 |
The Pyridine Ring of NAD Is Formed by a Nonenzymatic Pericyclic Reaction
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January 2005 |
Characterization of Quinolinate Synthases from Escherichia coli , Mycobacterium tuberculosis , and Pyrococcus horikoshii Indicates That [4Fe-4S] Clusters Are Common Cofactors throughout This Class of Enzymes †
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October 2008 |
Structure of Quinolinate Synthase from Pyrococcus horikoshii in the Presence of Its Product, Quinolinic Acid
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June 2016 |
NAD Biosynthesis
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December 2003 |
Nicotinamide adenine dinucleotide biosynthesis and pyridine nucleotide cycle metabolism in microbial systems.
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January 1980 |
Microbial NAD Metabolism: Lessons from Comparative Genomics
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September 2009 |
An Unexpected Species Determined by X-ray Crystallography that May Represent an Intermediate in the Reaction Catalyzed by Quinolinate Synthase
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August 2019 |
Prokaryotic Homologs of the Eukaryotic 3-Hydroxyanthranilate 3,4-Dioxygenase and 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase in the 2-Nitrobenzoate Degradation Pathway of Pseudomonas fluorescens Strain KU-7
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March 2003 |
Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis † , ‡
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May 2005 |
Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site
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March 2017 |
The 2-His-1-Carboxylate Facial Triad - An Emerging Structural Motif in Mononuclear Non-Heme Iron(II) Enzymes
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December 1997 |
An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE
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April 2015 |
Adapting to oxygen: 3-Hydroxyanthrinilate 3,4-dioxygenase employs loop dynamics to accommodate two substrates with disparate polarities
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May 2018 |
3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.
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June 1988 |
Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain
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January 1983 |
Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice
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July 1994 |
3-Hydroxyanthranilic acid accumulation following administration of the 3-hydroxyanthranilic acid 3,4-dioxygenase inhibitor NCR-631
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December 1999 |
Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver
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July 2003 |
The Mechanism of Inactivation of 3-Hydroxyanthranilate-3,4-dioxygenase by 4-Chloro-3-hydroxyanthranilate †
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May 2005 |
Endogenous kynurenines as targets for drug discovery and development
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August 2002 |
Tryptophan Metabolites and Brain Disorders
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January 2003 |
The kynurenine pathway of tryptophan degradation as a drug target
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February 2004 |
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
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May 1986 |
O 2 -Evolving Chlorite Dismutase as a Tool for Studying O 2 -Utilizing Enzymes
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February 2012 |
EPR and Mössbauer Spectroscopy Show Inequivalent Hemes in Tryptophan Dioxygenase
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January 2010 |
Crystal Structures of Fe2+ Dioxygenase Superoxo, Alkylperoxo, and Bound Product Intermediates
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journal
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April 2007 |
Crystal structures of alkylperoxo and anhydride intermediates in an intradiol ring-cleaving dioxygenase
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December 2014 |
Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action
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January 2015 |
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
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October 2016 |
A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism
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November 2016 |
Theory of ESR Linewidths of Free Radicals
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October 1960 |
Electron Paramagnetic Resonance and Nuclear Magnetic Resonance Studies of Class I Ribonucleotide Reductase
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June 1996 |
Protein Radicals in Enzyme Catalysis
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April 1998 |
Trapping and spectroscopic characterization of an FeIII-superoxo intermediate from a nonheme mononuclear iron-containing enzyme
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September 2010 |
Protein Crystals as Novel Catalytic Materials
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June 2001 |
Direct measurement of reactivity in the protein crystal by steady-state kinetic studies
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October 1995 |
Oxygen activation by mononuclear nonheme iron dioxygenases involved in the degradation of aromatics
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January 2017 |
Mechanism for Catechol Ring-Cleavage by Non-Heme Iron Extradiol Dioxygenases
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July 2004 |
A comparison of the reaction mechanisms of iron- and manganese-containing 2,3-HPCD: an important spin transition for manganese
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May 2008 |
A density functional investigation of the extradiol cleavage mechanism in non-heme iron catechol dioxygenases
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February 2003 |
Insights into the Mechanism of Aromatic Ring Cleavage of Noncatecholic Compound 2-Aminophenol by Aminophenol Dioxygenase: A Quantum Mechanics/Molecular Mechanics Study
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journal
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May 2016 |
Structures of aminophenol dioxygenase in complex with intermediate, product and inhibitor
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December 2012 |
Visualizing the substrate-, superoxo-, alkylperoxo-, and product-bound states at the nonheme Fe(II) site of homogentisate dioxygenase
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July 2013 |
Single-Turnover Kinetics of Homoprotocatechuate 2,3-Dioxygenase †
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journal
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December 2004 |
Substrate Binding Mechanism of a Type I Extradiol Dioxygenase
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journal
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September 2010 |
Mechanism of extradiol aromatic ring-cleaving dioxygenases
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December 2008 |
Definitive Evidence for Monoanionic Binding of 2,3-Dihydroxybiphenyl to 2,3-Dihydroxybiphenyl 1,2-Dioxygenase from UV Resonance Raman Spectroscopy, UV/Vis Absorption Spectroscopy, and Crystallography
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March 2002 |
The Role of the Conserved Residues His-246, His-199, and Tyr-255 in the Catalysis of Catechol 2,3-Dioxygenase from Pseudomonas stutzeri OX1
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journal
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September 2004 |
Crystal Structure and Functional Analysis of the Extradiol Dioxygenase LapB from a Long-chain Alkylphenol Degradation Pathway in Pseudomonas
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October 2009 |
Intermediate in the O−O Bond Cleavage Reaction of an Extradiol Dioxygenase † , ‡
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October 2008 |
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
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journal
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July 2017 |
Kinetic and Spectroscopic Characterization of ACMSD from Pseudomonas fluorescens Reveals a Pentacoordinate Mononuclear Metallocofactor
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September 2005 |
Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): A structural and mechanistic unveiling: Substrate Positioning in Human ACMSD
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November 2014 |
Quaternary structure of α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSD) controls its activity
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June 2019 |
The Power of Two: ARGININE 51 AND ARGININE 239* FROM A NEIGHBORING SUBUNIT ARE ESSENTIAL FOR CATALYSIS IN α-AMINO-β-CARBOXYMUCONATE-ϵ-SEMIALDEHYDE DECARBOXYLASE
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September 2013 |
α-Amino-β-carboxymuconic-ε-semialdehyde Decarboxylase (ACMSD) Is a New Member of the Amidohydrolase Superfamily †
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May 2006 |
Excretion of tryptophan-niacin metabolites by young men: effects of tryptophan, leucine, and vitamin B6 intakes
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October 1980 |
Quinolinic acid accumulation and functional deficits following experimental spinal cord injury
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January 1995 |
Photosystem II single crystals studied by EPR spectroscopy at 94 GHz: The tyrosine radical YFormula
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journal
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May 2001 |
Extending electron paramagnetic resonance to nanoliter volume protein single crystals using a self-resonant microhelix
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October 2019 |
Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data
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journal
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March 2003 |
Observing a ring-cleaving dioxygenase in action through a crystalline lens - a substrate monodentately bound structure
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January 2020 |
Probing extradiol dioxygenase mechanism in NAD(+) biosynthesis by viewing reaction cycle intermediates - a substrate bidentately bound structure
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January 2020 |
Observing a ring-cleaving dioxygenase in action through a crystalline lens - a superoxo bound structure
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January 2020 |
Observing a ring-cleaving dioxygenase in action through a crystalline lens - an alkylperoxo bound structure
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January 2020 |
Observing a ring-cleaving dioxygenase in action through a crystalline lens - a seven-membered lactone bound structure
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January 2020 |
Observing a ring-cleaving dioxygenase in action through a crystalline lens - an enol tautomer of ACMS monodentately bound structure
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January 2020 |
Observing a ring-cleaving dioxygenase in action through a crystalline lens - enol tautomers of ACMS bidentately bound structure
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January 2020 |
UCSF ChimeraX: Meeting modern challenges in visualization and analysis: UCSF ChimeraX Visualization System
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September 2017 |