Radioarsenic: A promising theragnostic candidate for nuclear medicine

Sanders, Vanessa A.; Cutler, Cathy S.

doi:10.1016/j.nucmedbio.2020.03.004

Title: Radioarsenic: A promising theragnostic candidate for nuclear medicine

Journal Article · Mon Apr 13 00:00:00 EDT 2020 · Nuclear Medicine and Biology

DOI:https://doi.org/10.1016/j.nucmedbio.2020.03.004· OSTI ID:1644010

^[1]; Cutler, Cathy S. ^[1]

Brookhaven National Lab. (BNL), Upton, NY (United States)

Molecular imaging is a non-invasive process that enable the visualization, characterization, and quantitation of biological processes at the molecular and cellular level. With the emergence of theragnostic agents to diagnose and treat disease for personalized medicine there is a growing need for matched pairs of isotopes. Matched pairs offer the unique opportunity to obtain patient specific information from SPECT or PET diagnostic studies to quantitate in vivo function or receptor density to inform and tailor therapeutic treatment. There are several isotopes of arsenic that have emissions suitable for either or both diagnostic imaging and radiotherapy. Their half-lives are long enough to pair them with peptides and antibodies which take longer to reach maximum uptake to facilitate improved patient pharmacokinetics and dosimetry then can be obtained with shorter lived radionuclides. Arsenic-72 even offers availability from a generator that can be shipped to remote sites and thus enhances availability. Arsenic has a long history as a diagnostic agent, but until recently has suffered from limited availability, lack of suitable chelators, and concerns about toxicity have inhibited its use in nuclear medicine. However, new production methods and novel chelators are coming online and the use of radioarsenic in the pico and nanomolar scale is well below the limits associated with toxicity. This manuscript will review the production routes, separation chemistry, radiolabeling techniques and in vitro/in vivo studies of three medically relevant isotopes of arsenic (arsenic-74, arsenic-72, and arsenic-77).

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Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: SC0012704; ST500120; ST6001034; YN0100000

OSTI ID:: 1644010

Alternate ID(s):: OSTI ID: 1809692

Report Number(s):: BNL-216197-2020-JAAM; TRN: US2201985

Journal Information:: Nuclear Medicine and Biology, Vol. 92; ISSN 0969-8051

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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